Enhanced GABAergic Inputs Contribute to Functional Alterations of Cholinergic Interneurons in the R6/2 Mouse Model of Huntington’s Disease1,2,3

Enhanced GABAergic Inputs Contribute to Functional Alterations of Cholinergic Interneurons in the R6/2 Mouse Model of Huntington’s Disease1,2,3

Although large cholinergic interneurons (LCIs) in striatum are spared in Huntington's disease (HD), deficits in cholinergic function have been described. Here we demonstrate in a mouse model of HD that the firing patterns of LCIs are disrupted and this is due to aberrant GABAergic neurotransmis...

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Bibliographic Details
Main Authors: Holley, Sandra M., Joshi, Prasad R., Parievsky, Anna, Galvan, Laurie, Chen, Jane Y., Fisher, Yvette E., Huynh, My N., Cepeda, Carlos, Levine, Michael S.
Format: Online
Language:English
Published: Society for Neuroscience 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507822/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507822/

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