A Rac/Cdc42 exchange factor complex promotes formation of lateral filopodia and blood vessel lumen morphogenesis

A Rac/Cdc42 exchange factor complex promotes formation of lateral filopodia and blood vessel lumen morphogenesis

During angiogenesis, Rho-GTPases influence endothelial cell migration and cell–cell adhesion; however it is not known whether they control formation of vessel lumens, which are essential for blood flow. Here, using an organotypic system that recapitulates distinct stages of VEGF-dependent angiogenes...

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Bibliographic Details
Main Authors: Abraham, Sabu, Scarcia, Margherita, Bagshaw, Richard D., McMahon, Kathryn, Grant, Gary, Harvey, Tracey, Yeo, Maggie, Esteves, Filomena O.G., Thygesen, Helene H., Jones, Pamela F., Speirs, Valerie, Hanby, Andrew M., Selby, Peter J., Lorger, Mihaela, Dear, T. Neil, Pawson, Tony, Marshall, Christopher J., Mavria, Georgia
Format: Online
Language:English
Published: Nature Pub. Group 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507007/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507007/

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