Disentangling perceptual judgment and online feedback deficits in Parkinson’s freezing of gait

Although the underlying mechanisms of freezing of gait in Parkinson’s disease (PD) are not fully understood, impaired sensory–perceptual processing has been proposed as an important contributor to freezing episodes. The aims of this cross-sectional study were to disentangle how sensory–perceptual de...

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Main Authors:	Silveira, Carolina R. A., Ehgoetz Martens, Kaylena A., Pieruccini-Faria, Frederico, Bell-Boucher, Danielle, Roy, Eric A., Almeida, Quincy J.
Format:	Online
Language:	English
Published:	Springer Berlin Heidelberg 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4503856/

id	pubmed-4503856
recordtype	oai_dc
spelling	pubmed-45038562015-07-17 Disentangling perceptual judgment and online feedback deficits in Parkinson’s freezing of gait Silveira, Carolina R. A. Ehgoetz Martens, Kaylena A. Pieruccini-Faria, Frederico Bell-Boucher, Danielle Roy, Eric A. Almeida, Quincy J. Original Communication Although the underlying mechanisms of freezing of gait in Parkinson’s disease (PD) are not fully understood, impaired sensory–perceptual processing has been proposed as an important contributor to freezing episodes. The aims of this cross-sectional study were to disentangle how sensory–perceptual deficits involved in planning (prior to movement) and sensory–perceptual feedback processing (during movement execution) contribute to freezing of gait in narrow spaces. Thirteen PD participants with freezing (PD FOG), 14 PD participants without freezing (PD non-FOG), and 15 healthy individuals made a perceptual estimate of the width of the distal opening of a corridor in two conditions: parallel and narrowing walls. Gait characteristics and number of freezing episodes were then compared while participants walked in baseline (no corridor), and through parallel walls and narrowing walls corridors. Visuospatial abilities were also assessed using neuropsychological tests. PD FOG had lower scores in the copy of the pentagons (p = 0.044) and had greater error variability in the perceptual judgment task (p = 0.008) than healthy participants. Although a similar number of freezing episodes occurred in both corridor conditions, PD FOG had greater step length variability while walking through the parallel walls corridor compared to healthy (p < 0.001) and PD non-FOG (p = 0.017) participants. Regression analysis revealed that error variability in perceptual judgment predicted the percentage of time spent in double support (R2 = 0.347) only in the narrowing walls condition for PD FOG. These results support the notion that sensory–perceptual deficits both prior to movement planning and during movement execution are important factors contributing to freezing of gait. Springer Berlin Heidelberg 2015-05-01 2015 /pmc/articles/PMC4503856/ /pubmed/25929667 http://dx.doi.org/10.1007/s00415-015-7759-7 Text en © The Author(s) 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Silveira, Carolina R. A. Ehgoetz Martens, Kaylena A. Pieruccini-Faria, Frederico Bell-Boucher, Danielle Roy, Eric A. Almeida, Quincy J.
spellingShingle	Silveira, Carolina R. A. Ehgoetz Martens, Kaylena A. Pieruccini-Faria, Frederico Bell-Boucher, Danielle Roy, Eric A. Almeida, Quincy J. Disentangling perceptual judgment and online feedback deficits in Parkinson’s freezing of gait
author_facet	Silveira, Carolina R. A. Ehgoetz Martens, Kaylena A. Pieruccini-Faria, Frederico Bell-Boucher, Danielle Roy, Eric A. Almeida, Quincy J.
author_sort	Silveira, Carolina R. A.
title	Disentangling perceptual judgment and online feedback deficits in Parkinson’s freezing of gait
title_short	Disentangling perceptual judgment and online feedback deficits in Parkinson’s freezing of gait
title_full	Disentangling perceptual judgment and online feedback deficits in Parkinson’s freezing of gait
title_fullStr	Disentangling perceptual judgment and online feedback deficits in Parkinson’s freezing of gait
title_full_unstemmed	Disentangling perceptual judgment and online feedback deficits in Parkinson’s freezing of gait
title_sort	disentangling perceptual judgment and online feedback deficits in parkinson’s freezing of gait
description	Although the underlying mechanisms of freezing of gait in Parkinson’s disease (PD) are not fully understood, impaired sensory–perceptual processing has been proposed as an important contributor to freezing episodes. The aims of this cross-sectional study were to disentangle how sensory–perceptual deficits involved in planning (prior to movement) and sensory–perceptual feedback processing (during movement execution) contribute to freezing of gait in narrow spaces. Thirteen PD participants with freezing (PD FOG), 14 PD participants without freezing (PD non-FOG), and 15 healthy individuals made a perceptual estimate of the width of the distal opening of a corridor in two conditions: parallel and narrowing walls. Gait characteristics and number of freezing episodes were then compared while participants walked in baseline (no corridor), and through parallel walls and narrowing walls corridors. Visuospatial abilities were also assessed using neuropsychological tests. PD FOG had lower scores in the copy of the pentagons (p = 0.044) and had greater error variability in the perceptual judgment task (p = 0.008) than healthy participants. Although a similar number of freezing episodes occurred in both corridor conditions, PD FOG had greater step length variability while walking through the parallel walls corridor compared to healthy (p < 0.001) and PD non-FOG (p = 0.017) participants. Regression analysis revealed that error variability in perceptual judgment predicted the percentage of time spent in double support (R2 = 0.347) only in the narrowing walls condition for PD FOG. These results support the notion that sensory–perceptual deficits both prior to movement planning and during movement execution are important factors contributing to freezing of gait.
publisher	Springer Berlin Heidelberg
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4503856/
_version_	1613248395228479488

Disentangling perceptual judgment and online feedback deficits in Parkinson’s freezing of gait

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