BAX and BAK1 are dispensable for ABT-737-induced dissociation of the BCL2-BECN1 complex and autophagy

BAX and BAK1 are dispensable for ABT-737-induced dissociation of the BCL2-BECN1 complex and autophagy

Disruption of the complex of BECN1 with BCL2 or BCL2L1/BCL-XL is an essential switch that turns on cellular autophagy in response to environmental stress or treatment with BH3 peptidomimetics. Recently, it has been proposed that BCL2 and BCL2L1/BCL-XL may inhibit autophagy indirectly through a mecha...

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Bibliographic Details
Main Authors: Pedro, Jose Manuel Bravo-San, Wei, Yongjie, Sica, Valentina, Maiuri, Maria Chiara, Zou, Zhongju, Kroemer, Guido, Levine, Beth
Format: Online
Language:English
Published: Taylor & Francis 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502763/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502763/

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