Hypoxia is an effective stimulus for vesicular release of ATP from human umbilical vein endothelial cells

•Hypoxia releases ATP from Human umbilical vein endothelial cells (HUVEC).•This ATP release is preferentially from apical surfaces.•Polarised ATP release is also triggered by Ca2+ ionophore.•Hypoxia-induced ATP release occurs from vesicles, as visualised by quinacrine.•It is attenuated by inhibitors...

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Bibliographic Details
Main Authors: Lim To, W.K., Kumar, P., Marshall, J.M.
Format: Online
Language:English
Published: W.B. Saunders 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502406/