Fast and scalable inference of multi-sample cancer lineages

Somatic variants can be used as lineage markers for the phylogenetic reconstruction of cancer evolution. Since somatic phylogenetics is complicated by sample heterogeneity, novel specialized tree-building methods are required for cancer phylogeny reconstruction. We present LICHeE (Lineage Inference...

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Bibliographic Details
Main Authors: Popic, Victoria, Salari, Raheleh, Hajirasouliha, Iman, Kashef-Haghighi, Dorna, West, Robert B, Batzoglou, Serafim
Format: Online
Language:English
Published: BioMed Central 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501097/