Ortho-methylated 3-hydroxypyridines hinder hen egg-white lysozyme fibrillogenesis

Protein aggregation with the concomitant formation of amyloid fibrils is related to several neurodegenerative diseases, but also to non-neuropathic amyloidogenic diseases and non-neurophatic systemic amyloidosis. Lysozyme is the protein involved in the latter, and it is widely used as a model system...

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Bibliographic Details
Main Authors: Mariño, Laura, Pauwels, Kris, Casasnovas, Rodrigo, Sanchis, Pilar, Vilanova, Bartolomé, Muñoz, Francisco, Donoso, Josefa, Adrover, Miquel
Format: Online
Language:English
Published: Nature Publishing Group 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500996/