AMPK Signaling Involvement for the Repression of the IL-1β-Induced Group IIA Secretory Phospholipase A2 Expression in VSMCs

AMPK Signaling Involvement for the Repression of the IL-1β-Induced Group IIA Secretory Phospholipase A2 Expression in VSMCs

Secretory Phospholipase A2 of type IIA (sPLA2 IIA) plays a crucial role in the production of lipid mediators by amplifying the neointimal inflammatory context of the vascular smooth muscle cells (VSMCs), especially during atherogenesis. Phenformin, a biguanide family member, by its anti-inflammatory...

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Bibliographic Details
Main Authors: El Hadri, Khadija, Denoyelle, Chantal, Ravaux, Lucas, Viollet, Benoit, Foretz, Marc, Friguet, Bertrand, Rouis, Mustapha, Raymondjean, Michel
Format: Online
Language:English
Published: Public Library of Science 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498592/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498592/

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