Sonochemotherapy: from bench to bedside

The combination of microbubbles and ultrasound has emerged as a promising method for local drug delivery. Microbubbles can be locally activated by a targeted ultrasound beam, which can result in several bio-effects. For drug delivery, microbubble-assisted ultrasound is used to increase vascular- and...

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Main Authors:	Lammertink, Bart H. A., Bos, Clemens, Deckers, Roel, Storm, Gert, Moonen, Chrit T. W., Escoffre, Jean-Michel
Format:	Online
Language:	English
Published:	Frontiers Media S.A. 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498442/

id	pubmed-4498442
recordtype	oai_dc
spelling	pubmed-44984422015-07-27 Sonochemotherapy: from bench to bedside Lammertink, Bart H. A. Bos, Clemens Deckers, Roel Storm, Gert Moonen, Chrit T. W. Escoffre, Jean-Michel Pharmacology The combination of microbubbles and ultrasound has emerged as a promising method for local drug delivery. Microbubbles can be locally activated by a targeted ultrasound beam, which can result in several bio-effects. For drug delivery, microbubble-assisted ultrasound is used to increase vascular- and plasma membrane permeability for facilitating drug extravasation and the cellular uptake of drugs in the treated region, respectively. In the case of drug-loaded microbubbles, these two mechanisms can be combined with local release of the drug following destruction of the microbubble. The use of microbubble-assisted ultrasound to deliver chemotherapeutic agents is also referred to as sonochemotherapy. In this review, the basic principles of sonochemotherapy are discussed, including aspects such as the type of (drug-loaded) microbubbles used, the routes of administration used in vivo, ultrasound devices and parameters, treatment schedules and safety issues. Finally, the clinical translation of sonochemotherapy is discussed, including the first clinical study using sonochemotherapy. Frontiers Media S.A. 2015-07-10 /pmc/articles/PMC4498442/ /pubmed/26217226 http://dx.doi.org/10.3389/fphar.2015.00138 Text en Copyright © 2015 Lammertink, Bos, Deckers, Storm, Moonen and Escoffre. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Lammertink, Bart H. A. Bos, Clemens Deckers, Roel Storm, Gert Moonen, Chrit T. W. Escoffre, Jean-Michel
spellingShingle	Lammertink, Bart H. A. Bos, Clemens Deckers, Roel Storm, Gert Moonen, Chrit T. W. Escoffre, Jean-Michel Sonochemotherapy: from bench to bedside
author_facet	Lammertink, Bart H. A. Bos, Clemens Deckers, Roel Storm, Gert Moonen, Chrit T. W. Escoffre, Jean-Michel
author_sort	Lammertink, Bart H. A.
title	Sonochemotherapy: from bench to bedside
title_short	Sonochemotherapy: from bench to bedside
title_full	Sonochemotherapy: from bench to bedside
title_fullStr	Sonochemotherapy: from bench to bedside
title_full_unstemmed	Sonochemotherapy: from bench to bedside
title_sort	sonochemotherapy: from bench to bedside
description	The combination of microbubbles and ultrasound has emerged as a promising method for local drug delivery. Microbubbles can be locally activated by a targeted ultrasound beam, which can result in several bio-effects. For drug delivery, microbubble-assisted ultrasound is used to increase vascular- and plasma membrane permeability for facilitating drug extravasation and the cellular uptake of drugs in the treated region, respectively. In the case of drug-loaded microbubbles, these two mechanisms can be combined with local release of the drug following destruction of the microbubble. The use of microbubble-assisted ultrasound to deliver chemotherapeutic agents is also referred to as sonochemotherapy. In this review, the basic principles of sonochemotherapy are discussed, including aspects such as the type of (drug-loaded) microbubbles used, the routes of administration used in vivo, ultrasound devices and parameters, treatment schedules and safety issues. Finally, the clinical translation of sonochemotherapy is discussed, including the first clinical study using sonochemotherapy.
publisher	Frontiers Media S.A.
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498442/
_version_	1613246456087445504

Sonochemotherapy: from bench to bedside

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