Head and neck cancer subtypes with biological and clinical relevance: Meta-analysis of gene-expression data

Head and neck cancer subtypes with biological and clinical relevance: Meta-analysis of gene-expression data

Head and neck squamous cell carcinoma (HNSCC) is a disease with heterogeneous clinical behavior and response to therapies. Despite the introduction of multimodality treatment, 40–50% of patients with advanced disease recur. Therefore, there is an urgent need to improve the classification beyond the...

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Bibliographic Details
Main Authors: De Cecco, Loris, Nicolau, Monica, Giannoccaro, Marco, Daidone, Maria Grazia, Bossi, Paolo, Locati, Laura, Licitra, Lisa, Canevari, Silvana
Format: Online
Language:English
Published: Impact Journals LLC 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496244/
Description
Summary:Head and neck squamous cell carcinoma (HNSCC) is a disease with heterogeneous clinical behavior and response to therapies. Despite the introduction of multimodality treatment, 40–50% of patients with advanced disease recur. Therefore, there is an urgent need to improve the classification beyond the current parameters in clinical use to better stratify patients and the therapeutic approaches. Following a meta-analysis approach we built a large training set to whom we applied a Disease-Specific Genomic Analysis (DSGA) to identify the disease component embedded into the tumor data. Eleven independent microarray datasets were used as validation sets.

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