A pentacyclic triterpene natural product, ursolic acid and its prodrug US597 inhibit targets within cell adhesion pathway and prevent cancer metastasis

A pentacyclic triterpene natural product, ursolic acid and its prodrug US597 inhibit targets within cell adhesion pathway and prevent cancer metastasis

Here we showed that ursolic acid (UA), a pentacyclic triterpene natural product, and its novel prodrug derivative US597 suppressed cancer cells adhesion, invasion and migration. This effect was accompanied by inhibition of focal adhesion signaling pathway including alterations in ICAM-1, VCAM-1, E-s...

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Bibliographic Details
Main Authors: Xiang, Liping, Chi, Ting, Tang, Qiao, Yang, Xiang, Ou, Minrui, Chen, Xiufen, Yu, Xiaobo, Chen, Jianzhong, Ho, Rodney J.Y., Shao, Jingwei, Jia, Lee
Format: Online
Language:English
Published: Impact Journals LLC 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496218/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496218/

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