A Cholera Conjugate Vaccine Containing O-specific Polysaccharide (OSP) of V. cholerae O1 Inaba and Recombinant Fragment of Tetanus Toxin Heavy Chain (OSP:rTTHc) Induces Serum, Memory and Lamina Proprial Responses against OSP and Is Protective in Mice

Cholera is a severely dehydrating diarrheal disease that remains an important global public health problem especially in developing countries. Globally, almost all cases of cholera are caused by V. cholerae O1. V. cholerae O1 organisms can be classified into two serotypes, Ogawa and Inaba, based on...

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Main Authors: Sayeed, Md. Abu, Bufano, Meagan Kelly, Xu, Peng, Eckhoff, Grace, Charles, Richelle C., Alam, Mohammad Murshid, Sultana, Tania, Rashu, Md. Rasheduzzaman, Berger, Amanda, Gonzalez-Escobedo, Geoffrey, Mandlik, Anjali, Bhuiyan, Taufiqur Rahman, Leung, Daniel T., LaRocque, Regina C., Harris, Jason B., Calderwood, Stephen B., Qadri, Firdausi, Vann, W. F., Kováč, Pavol, Ryan, Edward T.
Format: Online
Language:English
Published: Public Library of Science 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4495926/