Peptide Dose and/or Structure in Vaccines as a Determinant of T Cell Responses
While T cells recognise the complex of peptide and major histocompatibility complex (MHC) at the cell surface, changes in the dose and/or structure of the peptide component can have profound effects on T cell activation and function. In addition, the repertoire of T cells capable of responding to an...
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| Format: | Online |
| Language: | English |
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MDPI
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494221/ |
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pubmed-4494221 |
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pubmed-44942212015-08-31 Peptide Dose and/or Structure in Vaccines as a Determinant of T Cell Responses Leggatt, Graham R. Review While T cells recognise the complex of peptide and major histocompatibility complex (MHC) at the cell surface, changes in the dose and/or structure of the peptide component can have profound effects on T cell activation and function. In addition, the repertoire of T cells capable of responding to any given peptide is variable, but broader than a single clone. Consequently, peptide parameters that affect the interaction between T cells and peptide/MHC have been shown to select particular T cell clones for expansion and this impacts on clearance of disease. T cells with high functional avidity are selected on low doses of peptide, while low avidity T cells are favoured in high peptide concentrations. Altering the structure of the peptide ligand can also influence the selection and function of peptide-specific T cell clones. In this review, we will explore the evidence that the choice of peptide dose or the structure of the peptide are critical parameters in an effective vaccine designed to activate T cells. MDPI 2014-07-02 /pmc/articles/PMC4494221/ /pubmed/26344744 http://dx.doi.org/10.3390/vaccines2030537 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Leggatt, Graham R. |
| spellingShingle |
Leggatt, Graham R. Peptide Dose and/or Structure in Vaccines as a Determinant of T Cell Responses |
| author_facet |
Leggatt, Graham R. |
| author_sort |
Leggatt, Graham R. |
| title |
Peptide Dose and/or Structure in Vaccines as a Determinant of T Cell Responses |
| title_short |
Peptide Dose and/or Structure in Vaccines as a Determinant of T Cell Responses |
| title_full |
Peptide Dose and/or Structure in Vaccines as a Determinant of T Cell Responses |
| title_fullStr |
Peptide Dose and/or Structure in Vaccines as a Determinant of T Cell Responses |
| title_full_unstemmed |
Peptide Dose and/or Structure in Vaccines as a Determinant of T Cell Responses |
| title_sort |
peptide dose and/or structure in vaccines as a determinant of t cell responses |
| description |
While T cells recognise the complex of peptide and major histocompatibility complex (MHC) at the cell surface, changes in the dose and/or structure of the peptide component can have profound effects on T cell activation and function. In addition, the repertoire of T cells capable of responding to any given peptide is variable, but broader than a single clone. Consequently, peptide parameters that affect the interaction between T cells and peptide/MHC have been shown to select particular T cell clones for expansion and this impacts on clearance of disease. T cells with high functional avidity are selected on low doses of peptide, while low avidity T cells are favoured in high peptide concentrations. Altering the structure of the peptide ligand can also influence the selection and function of peptide-specific T cell clones. In this review, we will explore the evidence that the choice of peptide dose or the structure of the peptide are critical parameters in an effective vaccine designed to activate T cells. |
| publisher |
MDPI |
| publishDate |
2014 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494221/ |
| _version_ |
1613244982721773568 |