Th17-type cytokines, IL-6 and TNF-α synergistically activate STAT3 and NF-kB to promote colorectal cancer cell growth

Th17-type cytokines, IL-6 and TNF-α synergistically activate STAT3 and NF-kB to promote colorectal cancer cell growth

Colorectal cancers (CRCs) often show a dense infiltrate of cytokine-producing immune/inflammatory cells. The exact contribution of each immune cell subset and cytokine in the activation of the intracellular pathways sustaining CRC cell growth is not understood. Herein, we isolate tumor-infiltrating...

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Bibliographic Details
Main Authors: De Simone, V, Franzè, E, Ronchetti, G, Colantoni, A, Fantini, M C, Di Fusco, D, Sica, G S, Sileri, P, MacDonald, T T, Pallone, F, Monteleone, G, Stolfi, C
Format: Online
Language:English
Published: Nature Publishing Group 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493653/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493653/

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