Angiomotin binding-induced activation of Merlin/NF2 in the Hippo pathway

Angiomotin binding-induced activation of Merlin/NF2 in the Hippo pathway

The tumor suppressor Merlin/NF2 functions upstream of the core Hippo pathway kinases Lats1/2 and Mst1/2, as well as the nuclear E3 ubiquitin ligase CRL4DCAF1. Numerous mutations of Merlin have been identified in Neurofibromatosis type 2 and other cancer patients. Despite more than two decades of res...

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Bibliographic Details
Main Authors: Li, Youjun, Zhou, Hao, Li, Fengzhi, Chan, Siew Wee, Lin, Zhijie, Wei, Zhiyi, Yang, Zhou, Guo, Fusheng, Lim, Chun Jye, Xing, Wancai, Shen, Yuequan, Hong, Wanjin, Long, Jiafu, Zhang, Mingjie
Format: Online
Language:English
Published: Nature Publishing Group 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493278/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493278/

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