Irregular spiking of pyramidal neurons organizes as scale-invariant neuronal avalanches in the awake state
Spontaneous fluctuations in neuronal activity emerge at many spatial and temporal scales in cortex. Population measures found these fluctuations to organize as scale-invariant neuronal avalanches, suggesting cortical dynamics to be critical. Macroscopic dynamics, though, depend on physiological stat...
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| Format: | Online |
| Language: | English |
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eLife Sciences Publications, Ltd
2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492006/ |
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pubmed-4492006 |
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pubmed-44920062015-07-08 Irregular spiking of pyramidal neurons organizes as scale-invariant neuronal avalanches in the awake state Bellay, Timothy Klaus, Andreas Seshadri, Saurav Plenz, Dietmar Neuroscience Spontaneous fluctuations in neuronal activity emerge at many spatial and temporal scales in cortex. Population measures found these fluctuations to organize as scale-invariant neuronal avalanches, suggesting cortical dynamics to be critical. Macroscopic dynamics, though, depend on physiological states and are ambiguous as to their cellular composition, spatiotemporal origin, and contributions from synaptic input or action potential (AP) output. Here, we study spontaneous firing in pyramidal neurons (PNs) from rat superficial cortical layers in vivo and in vitro using 2-photon imaging. As the animal transitions from the anesthetized to awake state, spontaneous single neuron firing increases in irregularity and assembles into scale-invariant avalanches at the group level. In vitro spike avalanches emerged naturally yet required balanced excitation and inhibition. This demonstrates that neuronal avalanches are linked to the global physiological state of wakefulness and that cortical resting activity organizes as avalanches from firing of local PN groups to global population activity. eLife Sciences Publications, Ltd 2015-07-07 /pmc/articles/PMC4492006/ /pubmed/26151674 http://dx.doi.org/10.7554/eLife.07224 Text en http://creativecommons.org/publicdomain/zero/1.0/ This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication (http://creativecommons.org/publicdomain/zero/1.0/) . |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Bellay, Timothy Klaus, Andreas Seshadri, Saurav Plenz, Dietmar |
| spellingShingle |
Bellay, Timothy Klaus, Andreas Seshadri, Saurav Plenz, Dietmar Irregular spiking of pyramidal neurons organizes as scale-invariant neuronal avalanches in the awake state |
| author_facet |
Bellay, Timothy Klaus, Andreas Seshadri, Saurav Plenz, Dietmar |
| author_sort |
Bellay, Timothy |
| title |
Irregular spiking of pyramidal neurons organizes as scale-invariant neuronal avalanches in the awake state |
| title_short |
Irregular spiking of pyramidal neurons organizes as scale-invariant neuronal avalanches in the awake state |
| title_full |
Irregular spiking of pyramidal neurons organizes as scale-invariant neuronal avalanches in the awake state |
| title_fullStr |
Irregular spiking of pyramidal neurons organizes as scale-invariant neuronal avalanches in the awake state |
| title_full_unstemmed |
Irregular spiking of pyramidal neurons organizes as scale-invariant neuronal avalanches in the awake state |
| title_sort |
irregular spiking of pyramidal neurons organizes as scale-invariant neuronal avalanches in the awake state |
| description |
Spontaneous fluctuations in neuronal activity emerge at many spatial and temporal scales in cortex. Population measures found these fluctuations to organize as scale-invariant neuronal avalanches, suggesting cortical dynamics to be critical. Macroscopic dynamics, though, depend on physiological states and are ambiguous as to their cellular composition, spatiotemporal origin, and contributions from synaptic input or action potential (AP) output. Here, we study spontaneous firing in pyramidal neurons (PNs) from rat superficial cortical layers in vivo and in vitro using 2-photon imaging. As the animal transitions from the anesthetized to awake state, spontaneous single neuron firing increases in irregularity and assembles into scale-invariant avalanches at the group level. In vitro spike avalanches emerged naturally yet required balanced excitation and inhibition. This demonstrates that neuronal avalanches are linked to the global physiological state of wakefulness and that cortical resting activity organizes as avalanches from firing of local PN groups to global population activity. |
| publisher |
eLife Sciences Publications, Ltd |
| publishDate |
2015 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492006/ |
| _version_ |
1613244133367873536 |