Genetic Deletion and Pharmacological Inhibition of PI3Kγ Reduces Neutrophilic Airway Inflammation and Lung Damage in Mice with Cystic Fibrosis-Like Lung Disease

Genetic Deletion and Pharmacological Inhibition of PI3Kγ Reduces Neutrophilic Airway Inflammation and Lung Damage in Mice with Cystic Fibrosis-Like Lung Disease

Purpose. Neutrophil-dominated airway inflammation is a key feature of progressive lung damage in cystic fibrosis (CF). Thus, reducing airway inflammation is a major goal to prevent lung damage in CF. However, current anti-inflammatory drugs have shown several limits. PI3Kγ plays a pivotal role in l...

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Bibliographic Details
Main Authors: Galluzzo, Maria, Ciraolo, Elisa, Lucattelli, Monica, Hoxha, Eriola, Ulrich, Martina, Campa, Carlo Cosimo, Lungarella, Giuseppe, Doring, Gerd, Zhou-Suckow, Zhe, Mall, Marcus, Hirsch, Emilio, De Rose, Virginia
Format: Online
Language:English
Published: Hindawi Publishing Corporation 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491401/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491401/

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