Soluble CLEC2 Extracellular Domain Improves Glucose and Lipid Homeostasis by Regulating Liver Kupffer Cell Polarization

Soluble CLEC2 Extracellular Domain Improves Glucose and Lipid Homeostasis by Regulating Liver Kupffer Cell Polarization

The polarization of tissue resident macrophages toward the alternatively activated, anti-inflammatory M2 phenotype is believed to positively impact obesity and insulin resistance. Here we show that the soluble form of the extracellular domain (ECD) of C-type lectin-like receptor 2, CLEC2, regulates...

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Bibliographic Details
Main Authors: Wu, Xinle, Zhang, Jun, Ge, Hongfei, Gupte, Jamila, Baribault, Helene, Lee, Ki Jeong, Lemon, Bryan, Coberly, Suzanne, Gong, Yan, Pan, Zheng, Rulifson, Ingrid C., Gardner, Jonitha, Richards, William G., Li, Yang
Format: Online
Language:English
Published: Elsevier 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489977/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489977/

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