Reaching for the Holy Grail: insights from infection/cure models on the prospects for vaccines for Trypanosoma cruzi infection
Prevention of Trypanosoma cruzi infection in mammals likely depends on either prevention of the invading trypomastigotes from infecting host cells or the rapid recognition and killing of the newly infected cells by T. cruzi-specific T cells. We show here that multiple rounds of infection and cure (b...
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| Format: | Online |
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Instituto Oswaldo Cruz, Ministério da Saúde
2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489482/ |
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pubmed-44894822015-07-06 Reaching for the Holy Grail: insights from infection/cure models on the prospects for vaccines for Trypanosoma cruzi infection Bustamante, Juan Tarleton, Rick Articles Prevention of Trypanosoma cruzi infection in mammals likely depends on either prevention of the invading trypomastigotes from infecting host cells or the rapid recognition and killing of the newly infected cells by T. cruzi-specific T cells. We show here that multiple rounds of infection and cure (by drug therapy) fails to protect mice from reinfection, despite the generation of potent T cell responses. This disappointing result is similar to that obtained with many other vaccine protocols used in attempts to protect animals from T. cruzi infection. We have previously shown that immune recognition of T. cruzi infection is significantly delayed both at the systemic level and at the level of the infected host cell. The systemic delay appears to be the result of a stealth infection process that fails to trigger substantial innate recognition mechanisms while the delay at the cellular level is related to the immunodominance of highly variable gene family proteins, in particular those of the trans-sialidase family. Here we discuss how these previous studies and the new findings herein impact our thoughts on the potential of prophylactic vaccination to serve a productive role in the prevention of T. cruzi infection and Chagas disease. Instituto Oswaldo Cruz, Ministério da Saúde 2015-05 /pmc/articles/PMC4489482/ /pubmed/25946159 http://dx.doi.org/10.1590/0074-02760140440 Text en http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Bustamante, Juan Tarleton, Rick |
| spellingShingle |
Bustamante, Juan Tarleton, Rick Reaching for the Holy Grail: insights from infection/cure models on the prospects for vaccines for Trypanosoma cruzi infection |
| author_facet |
Bustamante, Juan Tarleton, Rick |
| author_sort |
Bustamante, Juan |
| title |
Reaching for the Holy Grail: insights from infection/cure models on the
prospects for vaccines for Trypanosoma cruzi
infection |
| title_short |
Reaching for the Holy Grail: insights from infection/cure models on the
prospects for vaccines for Trypanosoma cruzi
infection |
| title_full |
Reaching for the Holy Grail: insights from infection/cure models on the
prospects for vaccines for Trypanosoma cruzi
infection |
| title_fullStr |
Reaching for the Holy Grail: insights from infection/cure models on the
prospects for vaccines for Trypanosoma cruzi
infection |
| title_full_unstemmed |
Reaching for the Holy Grail: insights from infection/cure models on the
prospects for vaccines for Trypanosoma cruzi
infection |
| title_sort |
reaching for the holy grail: insights from infection/cure models on the
prospects for vaccines for trypanosoma cruzi
infection |
| description |
Prevention of Trypanosoma cruzi infection in mammals likely depends
on either prevention of the invading trypomastigotes from infecting host cells or the
rapid recognition and killing of the newly infected cells by T.
cruzi-specific T cells. We show here that multiple rounds of infection
and cure (by drug therapy) fails to protect mice from reinfection, despite the
generation of potent T cell responses. This disappointing result is similar to that
obtained with many other vaccine protocols used in attempts to protect animals
from T. cruzi infection. We have previously shown that immune
recognition of T. cruzi infection is significantly delayed both at
the systemic level and at the level of the infected host cell. The systemic delay
appears to be the result of a stealth infection process that fails to trigger
substantial innate recognition mechanisms while the delay at the cellular level is
related to the immunodominance of highly variable gene family proteins, in particular
those of the trans-sialidase family. Here we discuss how these previous studies and
the new findings herein impact our thoughts on the potential of prophylactic
vaccination to serve a productive role in the prevention of T. cruzi
infection and Chagas disease. |
| publisher |
Instituto Oswaldo Cruz, Ministério da Saúde |
| publishDate |
2015 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489482/ |
| _version_ |
1613243209826172928 |