GUIDANCE2: accurate detection of unreliable alignment regions accounting for the uncertainty of multiple parameters

Inference of multiple sequence alignments (MSAs) is a critical part of phylogenetic and comparative genomics studies. However, from the same set of sequences different MSAs are often inferred, depending on the methodologies used and the assumed parameters. Much effort has recently been devoted to im...

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Bibliographic Details
Main Authors: Sela, Itamar, Ashkenazy, Haim, Katoh, Kazutaka, Pupko, Tal
Format: Online
Language:English
Published: Oxford University Press 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489236/