Important Role of the IL-32 Inflammatory Network in the Host Response against Viral Infection
The pro-inflammatory cytokine interleukin (IL)-32 has gained much attention recently because of its important role in the inflammatory network. Since the discovery of IL-32 in 2005, our appreciation for its diverse roles continues to grow. Recent studies have discovered the antiviral effects induced...
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| Format: | Online |
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MDPI
2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488729/ |
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pubmed-44887292015-07-02 Important Role of the IL-32 Inflammatory Network in the Host Response against Viral Infection Zhou, Yaqin Zhu, Ying Review The pro-inflammatory cytokine interleukin (IL)-32 has gained much attention recently because of its important role in the inflammatory network. Since the discovery of IL-32 in 2005, our appreciation for its diverse roles continues to grow. Recent studies have discovered the antiviral effects induced by IL-32 and its associated regulatory mechanisms. The interactions between IL-32 and various cytokines including cyclooxygenase 2 (COX-2), inducible nitric oxide synthase (iNOS), interferon (IFN)-λ1, interleukin (IL)-6, and soluble IL-6 receptor have been described. This review aims to integrate these new findings into explicit concepts and raises the intriguing possibility of IL-32 as a therapeutic target. MDPI 2015-06-16 /pmc/articles/PMC4488729/ /pubmed/26087456 http://dx.doi.org/10.3390/v7062762 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Zhou, Yaqin Zhu, Ying |
| spellingShingle |
Zhou, Yaqin Zhu, Ying Important Role of the IL-32 Inflammatory Network in the Host Response against Viral Infection |
| author_facet |
Zhou, Yaqin Zhu, Ying |
| author_sort |
Zhou, Yaqin |
| title |
Important Role of the IL-32 Inflammatory Network in the Host Response against Viral Infection |
| title_short |
Important Role of the IL-32 Inflammatory Network in the Host Response against Viral Infection |
| title_full |
Important Role of the IL-32 Inflammatory Network in the Host Response against Viral Infection |
| title_fullStr |
Important Role of the IL-32 Inflammatory Network in the Host Response against Viral Infection |
| title_full_unstemmed |
Important Role of the IL-32 Inflammatory Network in the Host Response against Viral Infection |
| title_sort |
important role of the il-32 inflammatory network in the host response against viral infection |
| description |
The pro-inflammatory cytokine interleukin (IL)-32 has gained much attention recently because of its important role in the inflammatory network. Since the discovery of IL-32 in 2005, our appreciation for its diverse roles continues to grow. Recent studies have discovered the antiviral effects induced by IL-32 and its associated regulatory mechanisms. The interactions between IL-32 and various cytokines including cyclooxygenase 2 (COX-2), inducible nitric oxide synthase (iNOS), interferon (IFN)-λ1, interleukin (IL)-6, and soluble IL-6 receptor have been described. This review aims to integrate these new findings into explicit concepts and raises the intriguing possibility of IL-32 as a therapeutic target. |
| publisher |
MDPI |
| publishDate |
2015 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488729/ |
| _version_ |
1613242814667161600 |