Methodological Considerations in Estimation of Phenotype Heritability Using Genome-Wide SNP Data, Illustrated by an Analysis of the Heritability of Height in a Large Sample of African Ancestry Adults

Methodological Considerations in Estimation of Phenotype Heritability Using Genome-Wide SNP Data, Illustrated by an Analysis of the Heritability of Height in a Large Sample of African Ancestry Adults

Height has an extremely polygenic pattern of inheritance. Genome-wide association studies (GWAS) have revealed hundreds of common variants that are associated with human height at genome-wide levels of significance. However, only a small fraction of phenotypic variation can be explained by the aggre...

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Main Authors: Chen, Fang, He, Jing, Zhang, Jianqi, Chen, Gary K., Thomas, Venetta, Ambrosone, Christine B., Bandera, Elisa V., Berndt, Sonja I., Bernstein, Leslie, Blot, William J., Cai, Qiuyin, Carpten, John, Casey, Graham, Chanock, Stephen J., Cheng, Iona, Chu, Lisa, Deming, Sandra L., Driver, W. Ryan, Goodman, Phyllis, Hayes, Richard B., Hennis, Anselm J. M., Hsing, Ann W., Hu, Jennifer J., Ingles, Sue A., John, Esther M., Kittles, Rick A., Kolb, Suzanne, Leske, M. Cristina, Millikan, Robert C., Monroe, Kristine R., Murphy, Adam, Nemesure, Barbara, Neslund-Dudas, Christine, Nyante, Sarah, Ostrander, Elaine A, Press, Michael F., Rodriguez-Gil, Jorge L., Rybicki, Ben A., Schumacher, Fredrick, Stanford, Janet L., Signorello, Lisa B., Strom, Sara S., Stevens, Victoria, Van Den Berg, David, Wang, Zhaoming, Witte, John S., Wu, Suh-Yuh, Yamamura, Yuko, Zheng, Wei, Ziegler, Regina G., Stram, Alexander H., Kolonel, Laurence N., Marchand, Loïc Le, Henderson, Brian E., Haiman, Christopher A., Stram, Daniel O.
Format: Online
Language:English
Published: Public Library of Science 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488332/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488332/

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