Reduced Dopamine Transporter Availability and Neurocognitive Deficits in Male Patients with Alcohol Dependence

Dopamine plays an important role in the development of alcohol dependence, cognitive dysfunction, and is regulated via dopamine transporter activity. Although dopamine transporter activity is critically involved in alcohol dependence, studies observing this relationship are limited. Thus the current...

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Main Authors:	Yen, Che-Hung, Yeh, Yi-Wei, Liang, Chih-Sung, Ho, Pei-Shen, Kuo, Shin-Chang, Huang, Chang-Chih, Chen, Chun-Yen, Shih, Mei-Chen, Ma, Kuo-Hsing, Peng, Giia-Sheun, Lu, Ru-Band, Huang, San-Yuan
Format:	Online
Language:	English
Published:	Public Library of Science 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4487997/

id	pubmed-4487997
recordtype	oai_dc
spelling	pubmed-44879972015-07-02 Reduced Dopamine Transporter Availability and Neurocognitive Deficits in Male Patients with Alcohol Dependence Yen, Che-Hung Yeh, Yi-Wei Liang, Chih-Sung Ho, Pei-Shen Kuo, Shin-Chang Huang, Chang-Chih Chen, Chun-Yen Shih, Mei-Chen Ma, Kuo-Hsing Peng, Giia-Sheun Lu, Ru-Band Huang, San-Yuan Research Article Dopamine plays an important role in the development of alcohol dependence, cognitive dysfunction, and is regulated via dopamine transporter activity. Although dopamine transporter activity is critically involved in alcohol dependence, studies observing this relationship are limited. Thus the current study examined whether dopamine transporter availability is associated with developing of alcohol dependence and cognitive dysfunction. Brain imaging with 99mTc-TRODAT-1 as a ligand was used to measure dopamine transporter availability among 26 male patients with pure alcohol dependence and 22 age- and sex- matched healthy volunteers. The Wisconsin Card Sorting Test (WCST) and Tridimensional Personality Questionnaire (TPQ) were administered to assess neurocognitive functioning and personality traits, respectively. Compared to healthy controls, patients with alcohol dependence showed a significant reduction in dopamine transporter availability (p < 0.001), as well as diminished performance on the WCST (p < 0.001). Dopamine transporter availability was negatively correlated with both total and perseverative WCST errors among healthy controls, but only patients with alcohol dependence showed a positive correlation between dopamine transporter availability and a harm avoidance personality profile. Thus, reductions in dopamine transporter availability may play a pathophysiological role in the development of pure alcohol dependence, given its association with neurocognitive deficits. Moreover, personality may influence the development of pure alcohol dependence; however, additional clinical subgroups should be examined to confirm this possibility. Public Library of Science 2015-06-29 /pmc/articles/PMC4487997/ /pubmed/26120847 http://dx.doi.org/10.1371/journal.pone.0131017 Text en © 2015 Yen et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Yen, Che-Hung Yeh, Yi-Wei Liang, Chih-Sung Ho, Pei-Shen Kuo, Shin-Chang Huang, Chang-Chih Chen, Chun-Yen Shih, Mei-Chen Ma, Kuo-Hsing Peng, Giia-Sheun Lu, Ru-Band Huang, San-Yuan
spellingShingle	Yen, Che-Hung Yeh, Yi-Wei Liang, Chih-Sung Ho, Pei-Shen Kuo, Shin-Chang Huang, Chang-Chih Chen, Chun-Yen Shih, Mei-Chen Ma, Kuo-Hsing Peng, Giia-Sheun Lu, Ru-Band Huang, San-Yuan Reduced Dopamine Transporter Availability and Neurocognitive Deficits in Male Patients with Alcohol Dependence
author_facet	Yen, Che-Hung Yeh, Yi-Wei Liang, Chih-Sung Ho, Pei-Shen Kuo, Shin-Chang Huang, Chang-Chih Chen, Chun-Yen Shih, Mei-Chen Ma, Kuo-Hsing Peng, Giia-Sheun Lu, Ru-Band Huang, San-Yuan
author_sort	Yen, Che-Hung
title	Reduced Dopamine Transporter Availability and Neurocognitive Deficits in Male Patients with Alcohol Dependence
title_short	Reduced Dopamine Transporter Availability and Neurocognitive Deficits in Male Patients with Alcohol Dependence
title_full	Reduced Dopamine Transporter Availability and Neurocognitive Deficits in Male Patients with Alcohol Dependence
title_fullStr	Reduced Dopamine Transporter Availability and Neurocognitive Deficits in Male Patients with Alcohol Dependence
title_full_unstemmed	Reduced Dopamine Transporter Availability and Neurocognitive Deficits in Male Patients with Alcohol Dependence
title_sort	reduced dopamine transporter availability and neurocognitive deficits in male patients with alcohol dependence
description	Dopamine plays an important role in the development of alcohol dependence, cognitive dysfunction, and is regulated via dopamine transporter activity. Although dopamine transporter activity is critically involved in alcohol dependence, studies observing this relationship are limited. Thus the current study examined whether dopamine transporter availability is associated with developing of alcohol dependence and cognitive dysfunction. Brain imaging with 99mTc-TRODAT-1 as a ligand was used to measure dopamine transporter availability among 26 male patients with pure alcohol dependence and 22 age- and sex- matched healthy volunteers. The Wisconsin Card Sorting Test (WCST) and Tridimensional Personality Questionnaire (TPQ) were administered to assess neurocognitive functioning and personality traits, respectively. Compared to healthy controls, patients with alcohol dependence showed a significant reduction in dopamine transporter availability (p < 0.001), as well as diminished performance on the WCST (p < 0.001). Dopamine transporter availability was negatively correlated with both total and perseverative WCST errors among healthy controls, but only patients with alcohol dependence showed a positive correlation between dopamine transporter availability and a harm avoidance personality profile. Thus, reductions in dopamine transporter availability may play a pathophysiological role in the development of pure alcohol dependence, given its association with neurocognitive deficits. Moreover, personality may influence the development of pure alcohol dependence; however, additional clinical subgroups should be examined to confirm this possibility.
publisher	Public Library of Science
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4487997/
_version_	1613242451167805440

Reduced Dopamine Transporter Availability and Neurocognitive Deficits in Male Patients with Alcohol Dependence

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