Molecular evolution of haemagglutinin (H) gene in measles virus
We studied the molecular evolution of the haemagglutinin (H) gene (full length) in all genotypes (24 genotypes, 297 strains) of measles virus (MeV). The gene’s evolutionary timescale was estimated by the Bayesian Markov chain Monte Carlo (MCMC) method. We also analysed positive selection sites. The...
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| Format: | Online |
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Nature Publishing Group
2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486977/ |
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pubmed-44869772015-07-08 Molecular evolution of haemagglutinin (H) gene in measles virus Kimura, Hirokazu Saitoh, Mika Kobayashi, Miho Ishii, Haruyuki Saraya, Takeshi Kurai, Daisuke Tsukagoshi, Hiroyuki Shirabe, Komei Nishina, Atsuyoshi Kozawa, Kunihisa Kuroda, Makoto Takeuchi, Fumihiko Sekizuka, Tsuyoshi Minakami, Hisanori Ryo, Akihide Takeda, Makoto Article We studied the molecular evolution of the haemagglutinin (H) gene (full length) in all genotypes (24 genotypes, 297 strains) of measles virus (MeV). The gene’s evolutionary timescale was estimated by the Bayesian Markov chain Monte Carlo (MCMC) method. We also analysed positive selection sites. The MCMC tree indicated that the MeV H gene diverged from the rinderpest virus (same genus) about 250 years ago and that 24 MeV genotypes formed 3 lineages dating back to a 1915 ancestor (95% highest posterior density [HPD] 1882–1941) with relatively rapid evolution (mean rate: 9.02 × 10−4 substitutions/site/year). The 3 lineages diverged in 1915 (lineage 1, 95% HPD 1882–1941), 1954 (lineage 2, 95% HPD 1937–1969), and 1940 (lineage 3, 95% HPD 1927–1952). These 24 genotypes may have diverged and emerged between the 1940s and 1990s. Selective pressure analysis identified many negative selection sites on the H protein but only a few positive selection sites, suggesting strongly operated structural and/or functional constraint of changes on the H protein. Based on the molecular evolution of H gene, an ancestor MeV of the 24 genotypes emerged about 100 years ago and the structure of H protein has been well conserved. Nature Publishing Group 2015-07-01 /pmc/articles/PMC4486977/ /pubmed/26130388 http://dx.doi.org/10.1038/srep11648 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Kimura, Hirokazu Saitoh, Mika Kobayashi, Miho Ishii, Haruyuki Saraya, Takeshi Kurai, Daisuke Tsukagoshi, Hiroyuki Shirabe, Komei Nishina, Atsuyoshi Kozawa, Kunihisa Kuroda, Makoto Takeuchi, Fumihiko Sekizuka, Tsuyoshi Minakami, Hisanori Ryo, Akihide Takeda, Makoto |
| spellingShingle |
Kimura, Hirokazu Saitoh, Mika Kobayashi, Miho Ishii, Haruyuki Saraya, Takeshi Kurai, Daisuke Tsukagoshi, Hiroyuki Shirabe, Komei Nishina, Atsuyoshi Kozawa, Kunihisa Kuroda, Makoto Takeuchi, Fumihiko Sekizuka, Tsuyoshi Minakami, Hisanori Ryo, Akihide Takeda, Makoto Molecular evolution of haemagglutinin (H) gene in measles virus |
| author_facet |
Kimura, Hirokazu Saitoh, Mika Kobayashi, Miho Ishii, Haruyuki Saraya, Takeshi Kurai, Daisuke Tsukagoshi, Hiroyuki Shirabe, Komei Nishina, Atsuyoshi Kozawa, Kunihisa Kuroda, Makoto Takeuchi, Fumihiko Sekizuka, Tsuyoshi Minakami, Hisanori Ryo, Akihide Takeda, Makoto |
| author_sort |
Kimura, Hirokazu |
| title |
Molecular evolution of haemagglutinin (H) gene in measles virus |
| title_short |
Molecular evolution of haemagglutinin (H) gene in measles virus |
| title_full |
Molecular evolution of haemagglutinin (H) gene in measles virus |
| title_fullStr |
Molecular evolution of haemagglutinin (H) gene in measles virus |
| title_full_unstemmed |
Molecular evolution of haemagglutinin (H) gene in measles virus |
| title_sort |
molecular evolution of haemagglutinin (h) gene in measles virus |
| description |
We studied the molecular evolution of the haemagglutinin (H) gene (full length) in all genotypes (24 genotypes, 297 strains) of measles virus (MeV). The gene’s evolutionary timescale was estimated by the Bayesian Markov chain Monte Carlo (MCMC) method. We also analysed positive selection sites. The MCMC tree indicated that the MeV H gene diverged from the rinderpest virus (same genus) about 250 years ago and that 24 MeV genotypes formed 3 lineages dating back to a 1915 ancestor (95% highest posterior density [HPD] 1882–1941) with relatively rapid evolution (mean rate: 9.02 × 10−4 substitutions/site/year). The 3 lineages diverged in 1915 (lineage 1, 95% HPD 1882–1941), 1954 (lineage 2, 95% HPD 1937–1969), and 1940 (lineage 3, 95% HPD 1927–1952). These 24 genotypes may have diverged and emerged between the 1940s and 1990s. Selective pressure analysis identified many negative selection sites on the H protein but only a few positive selection sites, suggesting strongly operated structural and/or functional constraint of changes on the H protein. Based on the molecular evolution of H gene, an ancestor MeV of the 24 genotypes emerged about 100 years ago and the structure of H protein has been well conserved. |
| publisher |
Nature Publishing Group |
| publishDate |
2015 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486977/ |
| _version_ |
1613242144195084288 |