Uncleavable Nup98–Nup96 is functional in the fission yeast Schizosaccharomyces pombe

Uncleavable Nup98–Nup96 is functional in the fission yeast Schizosaccharomyces pombe

•Nup98 and Nup96 are produced via alternative splicing and autocleavage in S. pombe.•Splicing and autocleavage are both dispensable for S. pombe cell viability.•Nup98 and Nup96 expressed from different loci are functional for cell viability.•A Nup98–Nup96 joint molecule as a sole protein product of...

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Main Authors: Asakawa, Haruhiko, Mori, Chie, Ohtsuki, Chizuru, Iwamoto, Masaaki, Hiraoka, Yasushi, Haraguchi, Tokuko
Format: Online
Language:English
Published: Elsevier 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4483485/
id pubmed-4483485
recordtype oai_dc
spelling pubmed-44834852015-07-01 Uncleavable Nup98–Nup96 is functional in the fission yeast Schizosaccharomyces pombe Asakawa, Haruhiko Mori, Chie Ohtsuki, Chizuru Iwamoto, Masaaki Hiraoka, Yasushi Haraguchi, Tokuko Research article •Nup98 and Nup96 are produced via alternative splicing and autocleavage in S. pombe.•Splicing and autocleavage are both dispensable for S. pombe cell viability.•Nup98 and Nup96 expressed from different loci are functional for cell viability.•A Nup98–Nup96 joint molecule as a sole protein product of nup189 gene is functional.•Autocleavage is essential for Nup98 to remove a part of Nup96 generated by splicing. Elsevier 2015-06-12 /pmc/articles/PMC4483485/ /pubmed/26137436 http://dx.doi.org/10.1016/j.fob.2015.06.004 Text en © 2015 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Asakawa, Haruhiko
Mori, Chie
Ohtsuki, Chizuru
Iwamoto, Masaaki
Hiraoka, Yasushi
Haraguchi, Tokuko
spellingShingle Asakawa, Haruhiko
Mori, Chie
Ohtsuki, Chizuru
Iwamoto, Masaaki
Hiraoka, Yasushi
Haraguchi, Tokuko
Uncleavable Nup98–Nup96 is functional in the fission yeast Schizosaccharomyces pombe
author_facet Asakawa, Haruhiko
Mori, Chie
Ohtsuki, Chizuru
Iwamoto, Masaaki
Hiraoka, Yasushi
Haraguchi, Tokuko
author_sort Asakawa, Haruhiko
title Uncleavable Nup98–Nup96 is functional in the fission yeast Schizosaccharomyces pombe
title_short Uncleavable Nup98–Nup96 is functional in the fission yeast Schizosaccharomyces pombe
title_full Uncleavable Nup98–Nup96 is functional in the fission yeast Schizosaccharomyces pombe
title_fullStr Uncleavable Nup98–Nup96 is functional in the fission yeast Schizosaccharomyces pombe
title_full_unstemmed Uncleavable Nup98–Nup96 is functional in the fission yeast Schizosaccharomyces pombe
title_sort uncleavable nup98–nup96 is functional in the fission yeast schizosaccharomyces pombe
description •Nup98 and Nup96 are produced via alternative splicing and autocleavage in S. pombe.•Splicing and autocleavage are both dispensable for S. pombe cell viability.•Nup98 and Nup96 expressed from different loci are functional for cell viability.•A Nup98–Nup96 joint molecule as a sole protein product of nup189 gene is functional.•Autocleavage is essential for Nup98 to remove a part of Nup96 generated by splicing.
publisher Elsevier
publishDate 2015
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4483485/
_version_ 1613241150989139968

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