Central role for PICALM in amyloid–β blood–brain barrier transcytosis and clearance

Central role for PICALM in amyloid–β blood–brain barrier transcytosis and clearance

PICALM is highly validated genetic risk factor for Alzheimer’s disease (AD). Here, we report that PICALM reductions in AD and murine brain endothelium correlate with amyloid–β (Aβ) pathology and cognitive impairment. Moreover, Picalm deficiency diminishes Aβ clearance across the murine blood–brain b...

Full description

Bibliographic Details
Main Authors: Zhao, Zhen, Sagare, Abhay P., Ma, Qingyi, Halliday, Matthew R., Kong, Pan, Kisler, Kassandra, Winkler, Ethan A., Ramanathan, Anita, Kanekiyo, Takahisa, Bu, Guojun, Owens, Nelly Chuqui, Rege, Sanket V., Si, Gabriel, Ahuja, Ashim, Zhu, Donghui, Miller, Carol A., Schneider, Julie A., Maeda, Manami, Maeda, Takahiro, Sugawara, Tohru, Ichida, Justin K., Zlokovic, Berislav V.
Format: Online
Language:English
Published: 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482781/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482781/

Similar Items