Genetic disruption of uncoupling protein 1 in mice renders brown adipose tissue a significant source of FGF21 secretion

Genetic disruption of uncoupling protein 1 in mice renders brown adipose tissue a significant source of FGF21 secretion

•Genetic ablation of UCP1 increases FGF21 gene expression in adipose tissue.•The removal of adaptive nonshivering thermogenesis renders BAT a significant source of endogenous FGF21 under thermal stress.•The thermogenic competence of BAT is not a requirement for FGF21 secretion.

Bibliographic Details
Main Authors: Keipert, Susanne, Kutschke, Maria, Lamp, Daniel, Brachthäuser, Laura, Neff, Frauke, Meyer, Carola W., Oelkrug, Rebecca, Kharitonenkov, Alexei, Jastroch, Martin
Format: Online
Language:English
Published: Elsevier 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4481421/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4481421/

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