Dezocine Prevents Postoperative Hyperalgesia in Patients Undergoing Open Abdominal Surgery

Objective. Postoperative hyperalgesia is very frequent and hard to treat. Dezocine is widely used and has a modulatory effect for thermal hyperalgesia in animal models. So, this study was designed to investigate the potential role of dezocine in decreasing postoperative hyperalgesia for patients un...

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Main Authors:	Yu, Fang, Zhou, Jie, Xia, Suyun, Xu, Huan, Wang, Xiangrui
Format:	Online
Language:	English
Published:	Hindawi Publishing Corporation 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480811/

id	pubmed-4480811
recordtype	oai_dc
spelling	pubmed-44808112015-07-13 Dezocine Prevents Postoperative Hyperalgesia in Patients Undergoing Open Abdominal Surgery Yu, Fang Zhou, Jie Xia, Suyun Xu, Huan Wang, Xiangrui Research Article Objective. Postoperative hyperalgesia is very frequent and hard to treat. Dezocine is widely used and has a modulatory effect for thermal hyperalgesia in animal models. So, this study was designed to investigate the potential role of dezocine in decreasing postoperative hyperalgesia for patients undergoing open abdominal surgery. Methods. This is a randomized, double-blinded, and placebo-controlled trial. 50 patients for elective open gastrectomy were randomly allocated to either a true treatment group (0.15 mg/kg intravenous dezocine at the end of surgery) or a sham treatment group (equivalent volume of saline) in a 1 : 1 ratio. Patients were followed up for 48 hours postoperatively and pain threshold to Von Frey filaments, pain scores, PCIA consumption, rescue analgesics use, sedation score, and occurrence of postoperative nausea and vomiting were recorded. Results. Patients in the true treatment group experienced statistically significantly higher pain threshold on forearm and smaller extent of peri-incisional hyperalgesia than the sham treatment group. Rescue analgesic use, cumulative PCIA consumption, and pain scores were statistically significantly decreased in the true treatment group compared to the sham treatment group. Conclusions. Dezocine offers a significant antihyperalgesic and analgesic effect in patients undergoing elective open gastrectomy for up to 48 hours postoperatively. Hindawi Publishing Corporation 2015 2015-06-11 /pmc/articles/PMC4480811/ /pubmed/26170890 http://dx.doi.org/10.1155/2015/946194 Text en Copyright © 2015 Fang Yu et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Yu, Fang Zhou, Jie Xia, Suyun Xu, Huan Wang, Xiangrui
spellingShingle	Yu, Fang Zhou, Jie Xia, Suyun Xu, Huan Wang, Xiangrui Dezocine Prevents Postoperative Hyperalgesia in Patients Undergoing Open Abdominal Surgery
author_facet	Yu, Fang Zhou, Jie Xia, Suyun Xu, Huan Wang, Xiangrui
author_sort	Yu, Fang
title	Dezocine Prevents Postoperative Hyperalgesia in Patients Undergoing Open Abdominal Surgery
title_short	Dezocine Prevents Postoperative Hyperalgesia in Patients Undergoing Open Abdominal Surgery
title_full	Dezocine Prevents Postoperative Hyperalgesia in Patients Undergoing Open Abdominal Surgery
title_fullStr	Dezocine Prevents Postoperative Hyperalgesia in Patients Undergoing Open Abdominal Surgery
title_full_unstemmed	Dezocine Prevents Postoperative Hyperalgesia in Patients Undergoing Open Abdominal Surgery
title_sort	dezocine prevents postoperative hyperalgesia in patients undergoing open abdominal surgery
description	Objective. Postoperative hyperalgesia is very frequent and hard to treat. Dezocine is widely used and has a modulatory effect for thermal hyperalgesia in animal models. So, this study was designed to investigate the potential role of dezocine in decreasing postoperative hyperalgesia for patients undergoing open abdominal surgery. Methods. This is a randomized, double-blinded, and placebo-controlled trial. 50 patients for elective open gastrectomy were randomly allocated to either a true treatment group (0.15 mg/kg intravenous dezocine at the end of surgery) or a sham treatment group (equivalent volume of saline) in a 1 : 1 ratio. Patients were followed up for 48 hours postoperatively and pain threshold to Von Frey filaments, pain scores, PCIA consumption, rescue analgesics use, sedation score, and occurrence of postoperative nausea and vomiting were recorded. Results. Patients in the true treatment group experienced statistically significantly higher pain threshold on forearm and smaller extent of peri-incisional hyperalgesia than the sham treatment group. Rescue analgesic use, cumulative PCIA consumption, and pain scores were statistically significantly decreased in the true treatment group compared to the sham treatment group. Conclusions. Dezocine offers a significant antihyperalgesic and analgesic effect in patients undergoing elective open gastrectomy for up to 48 hours postoperatively.
publisher	Hindawi Publishing Corporation
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480811/
_version_	1613240200384741376

Dezocine Prevents Postoperative Hyperalgesia in Patients Undergoing Open Abdominal Surgery

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