MicroRNA-200a suppresses metastatic potential of side population cells in human hepatocellular carcinoma by decreasing ZEB2

Although microRNA-200a (miR-200a) is frequently downregulated in cancer, its role in side population (SP) has not been investigated. In this study, 101 pairs of primary hepatocellular carcinoma (HCC) tissues and matched normal control tissues were analyzed for miR-200a expression and its clinicopath...

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Main Authors:	Yang, Xisheng, Wang, Jianlin, Qu, Shibin, Zhang, Hongtao, Ruan, Bai, Gao, Yuan, Ma, Ben, Wang, Xing, Wu, Nan, Li, Xiaolei, Dou, Kefeng, Li, Haimin
Format:	Online
Language:	English
Published:	Impact Journals LLC 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480725/

id	pubmed-4480725
recordtype	oai_dc
spelling	pubmed-44807252015-06-26 MicroRNA-200a suppresses metastatic potential of side population cells in human hepatocellular carcinoma by decreasing ZEB2 Yang, Xisheng Wang, Jianlin Qu, Shibin Zhang, Hongtao Ruan, Bai Gao, Yuan Ma, Ben Wang, Xing Wu, Nan Li, Xiaolei Dou, Kefeng Li, Haimin Research Paper Although microRNA-200a (miR-200a) is frequently downregulated in cancer, its role in side population (SP) has not been investigated. In this study, 101 pairs of primary hepatocellular carcinoma (HCC) tissues and matched normal control tissues were analyzed for miR-200a expression and its clinicopathological value was determined. We found that miR-200a was downregulated in HCC/SP and this was associated metastasis. MiR-200a suppressed metastasis of SP cells. Overexpression of miR-200a in SP cells decreased metastasis-related markers and expression of ZEB2. The associations between miR-200a, SP cells and ZEB2 were validated in HCC. These findings reveal that miR-200a suppresses metastasis of SP cells by downregulating ZEB2. Impact Journals LLC 2015-03-08 /pmc/articles/PMC4480725/ /pubmed/25797260 Text en Copyright: © 2015 Yang et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Yang, Xisheng Wang, Jianlin Qu, Shibin Zhang, Hongtao Ruan, Bai Gao, Yuan Ma, Ben Wang, Xing Wu, Nan Li, Xiaolei Dou, Kefeng Li, Haimin
spellingShingle	Yang, Xisheng Wang, Jianlin Qu, Shibin Zhang, Hongtao Ruan, Bai Gao, Yuan Ma, Ben Wang, Xing Wu, Nan Li, Xiaolei Dou, Kefeng Li, Haimin MicroRNA-200a suppresses metastatic potential of side population cells in human hepatocellular carcinoma by decreasing ZEB2
author_facet	Yang, Xisheng Wang, Jianlin Qu, Shibin Zhang, Hongtao Ruan, Bai Gao, Yuan Ma, Ben Wang, Xing Wu, Nan Li, Xiaolei Dou, Kefeng Li, Haimin
author_sort	Yang, Xisheng
title	MicroRNA-200a suppresses metastatic potential of side population cells in human hepatocellular carcinoma by decreasing ZEB2
title_short	MicroRNA-200a suppresses metastatic potential of side population cells in human hepatocellular carcinoma by decreasing ZEB2
title_full	MicroRNA-200a suppresses metastatic potential of side population cells in human hepatocellular carcinoma by decreasing ZEB2
title_fullStr	MicroRNA-200a suppresses metastatic potential of side population cells in human hepatocellular carcinoma by decreasing ZEB2
title_full_unstemmed	MicroRNA-200a suppresses metastatic potential of side population cells in human hepatocellular carcinoma by decreasing ZEB2
title_sort	microrna-200a suppresses metastatic potential of side population cells in human hepatocellular carcinoma by decreasing zeb2
description	Although microRNA-200a (miR-200a) is frequently downregulated in cancer, its role in side population (SP) has not been investigated. In this study, 101 pairs of primary hepatocellular carcinoma (HCC) tissues and matched normal control tissues were analyzed for miR-200a expression and its clinicopathological value was determined. We found that miR-200a was downregulated in HCC/SP and this was associated metastasis. MiR-200a suppressed metastasis of SP cells. Overexpression of miR-200a in SP cells decreased metastasis-related markers and expression of ZEB2. The associations between miR-200a, SP cells and ZEB2 were validated in HCC. These findings reveal that miR-200a suppresses metastasis of SP cells by downregulating ZEB2.
publisher	Impact Journals LLC
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480725/
_version_	1613240167927119872

MicroRNA-200a suppresses metastatic potential of side population cells in human hepatocellular carcinoma by decreasing ZEB2

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