A transcriptomic signature mediated by HOXA9 promotes human glioblastoma initiation, aggressiveness and resistance to temozolomide

A transcriptomic signature mediated by HOXA9 promotes human glioblastoma initiation, aggressiveness and resistance to temozolomide

Glioblastoma is the most malignant brain tumor, exhibiting remarkable resistance to treatment. Here we investigated the oncogenic potential of HOXA9 in gliomagenesis, the molecular and cellular mechanisms by which HOXA9 renders glioblastoma more aggressive, and how HOXA9 affects response to chemothe...

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Bibliographic Details
Main Authors: Pojo, Marta, Gonçalves, Céline S., Xavier-Magalhães, Ana, Oliveira, Ana Isabel, Gonçalves, Tiago, Correia, Sara, Rodrigues, Ana J., Costa, Sandra, Pinto, Luísa, Pinto, Afonso A., Lopes, José M., Reis, Rui M., Rocha, Miguel, Sousa, Nuno, Costa, Bruno M.
Format: Online
Language:English
Published: Impact Journals LLC 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480707/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480707/

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