Sphingosine-1-phosphate as signaling molecule in the skin: Relevance in atopic dermatitis

Sphingolipids are essential molecules of the mammalian epidermis. Keratinocytes generate and secrete huge amounts of ceramide-precursors to the extracellular domain of the stratum corneum, where they are further metabolized to specific ceramide species. The arrangement of ceramides to well-organized...

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Bibliographic Details
Main Authors: Japtok, Lukasz, Bäumer, Wolfgang, Kleuser, Burkhard
Format: Online
Language:English
Published: Urban & Vogel 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479432/