Novel Genes Critical for Hypoxic Preconditioning in Zebrafish Are Regulators of Insulin and Glucose Metabolism

Severe hypoxia is a common cause of major brain, heart, and kidney injury in adults, children, and newborns. However, mild hypoxia can be protective against later, more severe hypoxia exposure via “hypoxic preconditioning,” a phenomenon that is not yet fully understood. Accordingly, we have establis...

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Main Authors:	Manchenkov, Tania, Pasillas, Martina P., Haddad, Gabriel G., Imam, Farhad B.
Format:	Online
Language:	English
Published:	Genetics Society of America 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4478541/

id	pubmed-4478541
recordtype	oai_dc
spelling	pubmed-44785412015-06-29 Novel Genes Critical for Hypoxic Preconditioning in Zebrafish Are Regulators of Insulin and Glucose Metabolism Manchenkov, Tania Pasillas, Martina P. Haddad, Gabriel G. Imam, Farhad B. Investigations Severe hypoxia is a common cause of major brain, heart, and kidney injury in adults, children, and newborns. However, mild hypoxia can be protective against later, more severe hypoxia exposure via “hypoxic preconditioning,” a phenomenon that is not yet fully understood. Accordingly, we have established and optimized an embryonic zebrafish model to study hypoxic preconditioning. Using a functional genomic approach, we used this zebrafish model to identify and validate five novel hypoxia-protective genes, including irs2, crtc3, and camk2g2, which have been previously implicated in metabolic regulation. These results extend our understanding of the mechanisms of hypoxic preconditioning and affirm the discovery potential of this novel vertebrate hypoxic stress model. Genetics Society of America 2015-04-03 /pmc/articles/PMC4478541/ /pubmed/25840431 http://dx.doi.org/10.1534/g3.115.018010 Text en Copyright © 2015 Manchenkov et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Unported License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Manchenkov, Tania Pasillas, Martina P. Haddad, Gabriel G. Imam, Farhad B.
spellingShingle	Manchenkov, Tania Pasillas, Martina P. Haddad, Gabriel G. Imam, Farhad B. Novel Genes Critical for Hypoxic Preconditioning in Zebrafish Are Regulators of Insulin and Glucose Metabolism
author_facet	Manchenkov, Tania Pasillas, Martina P. Haddad, Gabriel G. Imam, Farhad B.
author_sort	Manchenkov, Tania
title	Novel Genes Critical for Hypoxic Preconditioning in Zebrafish Are Regulators of Insulin and Glucose Metabolism
title_short	Novel Genes Critical for Hypoxic Preconditioning in Zebrafish Are Regulators of Insulin and Glucose Metabolism
title_full	Novel Genes Critical for Hypoxic Preconditioning in Zebrafish Are Regulators of Insulin and Glucose Metabolism
title_fullStr	Novel Genes Critical for Hypoxic Preconditioning in Zebrafish Are Regulators of Insulin and Glucose Metabolism
title_full_unstemmed	Novel Genes Critical for Hypoxic Preconditioning in Zebrafish Are Regulators of Insulin and Glucose Metabolism
title_sort	novel genes critical for hypoxic preconditioning in zebrafish are regulators of insulin and glucose metabolism
description	Severe hypoxia is a common cause of major brain, heart, and kidney injury in adults, children, and newborns. However, mild hypoxia can be protective against later, more severe hypoxia exposure via “hypoxic preconditioning,” a phenomenon that is not yet fully understood. Accordingly, we have established and optimized an embryonic zebrafish model to study hypoxic preconditioning. Using a functional genomic approach, we used this zebrafish model to identify and validate five novel hypoxia-protective genes, including irs2, crtc3, and camk2g2, which have been previously implicated in metabolic regulation. These results extend our understanding of the mechanisms of hypoxic preconditioning and affirm the discovery potential of this novel vertebrate hypoxic stress model.
publisher	Genetics Society of America
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4478541/
_version_	1613239490887811072

Novel Genes Critical for Hypoxic Preconditioning in Zebrafish Are Regulators of Insulin and Glucose Metabolism

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