IgG4-Associated Cholangitis Can Mimic Hilar Cholangiocarcinoma
IgG4-associated cholangitis can mimic hilar cholangiocarcinoma. Previously reported patients with IgG4-associated cholangitis mimicking cholangiocarcinoma had elevated serum IgG4 levels and long-segment biliary strictures. However, in the absence of other diagnostic criteria for malignancy, IgG4-ass...
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Gut and Liver
2015
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Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4478001/ |
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pubmed-44780012015-07-01 IgG4-Associated Cholangitis Can Mimic Hilar Cholangiocarcinoma Zaydfudim, Victor M. Wang, Andrew Y. de Lange, Eduard E. Zhao, Zimin Moskaluk, Christopher A. Bauer, Todd W. Adams, Reid B. Case Report IgG4-associated cholangitis can mimic hilar cholangiocarcinoma. Previously reported patients with IgG4-associated cholangitis mimicking cholangiocarcinoma had elevated serum IgG4 levels and long-segment biliary strictures. However, in the absence of other diagnostic criteria for malignancy, IgG4-associated cholangitis should remain a consideration among patients with normal serum IgG4 and a hilar mass suspicious for cholangiocarcinoma. The presence of a hilar mass and a malignant-appearing biliary stricture in two patients with normal serum IgG4 prompted further evaluation and subsequent concomitant liver and bile duct resection and reconstruction. The diagnosis of IgG4-associated cholangitis was established during the pathologic evaluation of the resected specimens. IgG4-associated cholangitis is a known imitator of hilar cholangiocarcinoma and should be considered in the differential diagnosis even among serologically IgG4-negative patients with a hilar mass prior to operative resection. Gut and Liver 2015-07 2015-06-04 /pmc/articles/PMC4478001/ /pubmed/26033685 http://dx.doi.org/10.5009/gnl14241 Text en Copyright © 2015 by The Korean Society of Gastroenterology, the Korean Society of Gastrointestinal Endoscopy, the Korean Society of Neurogastroenterology and Motility, Korean College of Helicobacter and Upper Gastrointestinal Research, Korean Association for the Study of Intestinal Diseases, the Korean Association for the Study of the Liver, Korean Pancreatobiliary Association, and Korean Society of Gastrointestinal Cancer. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
repository_type |
Open Access Journal |
institution_category |
Foreign Institution |
institution |
US National Center for Biotechnology Information |
building |
NCBI PubMed |
collection |
Online Access |
language |
English |
format |
Online |
author |
Zaydfudim, Victor M. Wang, Andrew Y. de Lange, Eduard E. Zhao, Zimin Moskaluk, Christopher A. Bauer, Todd W. Adams, Reid B. |
spellingShingle |
Zaydfudim, Victor M. Wang, Andrew Y. de Lange, Eduard E. Zhao, Zimin Moskaluk, Christopher A. Bauer, Todd W. Adams, Reid B. IgG4-Associated Cholangitis Can Mimic Hilar Cholangiocarcinoma |
author_facet |
Zaydfudim, Victor M. Wang, Andrew Y. de Lange, Eduard E. Zhao, Zimin Moskaluk, Christopher A. Bauer, Todd W. Adams, Reid B. |
author_sort |
Zaydfudim, Victor M. |
title |
IgG4-Associated Cholangitis Can Mimic Hilar Cholangiocarcinoma |
title_short |
IgG4-Associated Cholangitis Can Mimic Hilar Cholangiocarcinoma |
title_full |
IgG4-Associated Cholangitis Can Mimic Hilar Cholangiocarcinoma |
title_fullStr |
IgG4-Associated Cholangitis Can Mimic Hilar Cholangiocarcinoma |
title_full_unstemmed |
IgG4-Associated Cholangitis Can Mimic Hilar Cholangiocarcinoma |
title_sort |
igg4-associated cholangitis can mimic hilar cholangiocarcinoma |
description |
IgG4-associated cholangitis can mimic hilar cholangiocarcinoma. Previously reported patients with IgG4-associated cholangitis mimicking cholangiocarcinoma had elevated serum IgG4 levels and long-segment biliary strictures. However, in the absence of other diagnostic criteria for malignancy, IgG4-associated cholangitis should remain a consideration among patients with normal serum IgG4 and a hilar mass suspicious for cholangiocarcinoma. The presence of a hilar mass and a malignant-appearing biliary stricture in two patients with normal serum IgG4 prompted further evaluation and subsequent concomitant liver and bile duct resection and reconstruction. The diagnosis of IgG4-associated cholangitis was established during the pathologic evaluation of the resected specimens. IgG4-associated cholangitis is a known imitator of hilar cholangiocarcinoma and should be considered in the differential diagnosis even among serologically IgG4-negative patients with a hilar mass prior to operative resection. |
publisher |
Gut and Liver |
publishDate |
2015 |
url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4478001/ |
_version_ |
1613239326588534784 |