An HDAC2-TET1 switch at distinct chromatin regions significantly promotes the maturation of pre-iPS to iPS cells

An HDAC2-TET1 switch at distinct chromatin regions significantly promotes the maturation of pre-iPS to iPS cells

The maturation of induced pluripotent stem cells (iPS) is one of the limiting steps of somatic cell reprogramming, but the underlying mechanism is largely unknown. Here, we reported that knockdown of histone deacetylase 2 (HDAC2) specifically promoted the maturation of iPS cells. Further studies sho...

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Bibliographic Details
Main Authors: Wei, Tingyi, Chen, Wen, Wang, Xiukun, Zhang, Man, Chen, Jiayu, Zhu, Songcheng, Chen, Long, Yang, Dandan, Wang, Guiying, Jia, Wenwen, Yu, Yangyang, Duan, Tao, Wu, Minjuan, Liu, Houqi, Gao, Shaorong, Kang, Jiuhong
Format: Online
Language:English
Published: Oxford University Press 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477660/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477660/

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