Th17 and Th17/Treg ratio at early HIV infection associate with protective HIV-specific CD8+ T-cell responses and disease progression

Th17 and Th17/Treg ratio at early HIV infection associate with protective HIV-specific CD8+ T-cell responses and disease progression

The aim of this study was to analyze Th17 and Treg subsets and their correlation with anti-HIV T-cell responses and clinical parameters during (acute/early) primary HIV infection (PHI) and up to one year post-infection (p.i). Samples from 14 healthy donors (HDs), 40 PHI patients, 17 Chronics, and 13...

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Main Authors: Falivene, Juliana, Ghiglione, Yanina, Laufer, Natalia, Eugenia Socías, María, Pía Holgado, María, Julia Ruiz, María, Maeto, Cynthia, Inés Figueroa, María, Giavedoni, Luis D., Cahn, Pedro, Salomón, Horacio, Sued, Omar, Turk, Gabriela, Magdalena Gherardi, María
Format: Online
Language:English
Published: Nature Publishing Group 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477236/
id pubmed-4477236
recordtype oai_dc
spelling pubmed-44772362015-06-24 Th17 and Th17/Treg ratio at early HIV infection associate with protective HIV-specific CD8+ T-cell responses and disease progression Falivene, Juliana Ghiglione, Yanina Laufer, Natalia Eugenia Socías, María Pía Holgado, María Julia Ruiz, María Maeto, Cynthia Inés Figueroa, María Giavedoni, Luis D. Cahn, Pedro Salomón, Horacio Sued, Omar Turk, Gabriela Magdalena Gherardi, María Article The aim of this study was to analyze Th17 and Treg subsets and their correlation with anti-HIV T-cell responses and clinical parameters during (acute/early) primary HIV infection (PHI) and up to one year post-infection (p.i). Samples from 14 healthy donors (HDs), 40 PHI patients, 17 Chronics, and 13 Elite controllers (ECs) were studied. The percentages of Th17 and Treg subsets were severely altered in Chronics, whereas all HIV-infected individuals (including ECs) showed Th17/Treg imbalance compared to HDs, in concordance with higher frequencies of activated CD8+ T-cells (HLA-DR+/CD38+). Better clinical status (higher CD4 counts, lower viral loads and activation) was associated with higher Th17 and lower Treg levels. We found positive correlations between Th17 at baseline and anti-HIV CD8+ T-cell functionality: viral inhibitory activity (VIA) and key polyfunctions (IFN-γ+/CD107A/B+) at both early and later times p.i, highlighting the prognostic value of Th17 cells to preserve an effective HIV T-cell immunity. Th17/Treg ratio and the IL-17 relative mean fluorescence intensity (rMFI of IL-17) were also positively correlated with VIA. Taken together, our results suggested a potential link between Th17 and Th17/Treg ratio with key HIV-specific CD8+ T-cell responses against the infection. Nature Publishing Group 2015-06-23 /pmc/articles/PMC4477236/ /pubmed/26099972 http://dx.doi.org/10.1038/srep11511 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Falivene, Juliana
Ghiglione, Yanina
Laufer, Natalia
Eugenia Socías, María
Pía Holgado, María
Julia Ruiz, María
Maeto, Cynthia
Inés Figueroa, María
Giavedoni, Luis D.
Cahn, Pedro
Salomón, Horacio
Sued, Omar
Turk, Gabriela
Magdalena Gherardi, María
spellingShingle Falivene, Juliana
Ghiglione, Yanina
Laufer, Natalia
Eugenia Socías, María
Pía Holgado, María
Julia Ruiz, María
Maeto, Cynthia
Inés Figueroa, María
Giavedoni, Luis D.
Cahn, Pedro
Salomón, Horacio
Sued, Omar
Turk, Gabriela
Magdalena Gherardi, María
Th17 and Th17/Treg ratio at early HIV infection associate with protective HIV-specific CD8+ T-cell responses and disease progression
author_facet Falivene, Juliana
Ghiglione, Yanina
Laufer, Natalia
Eugenia Socías, María
Pía Holgado, María
Julia Ruiz, María
Maeto, Cynthia
Inés Figueroa, María
Giavedoni, Luis D.
Cahn, Pedro
Salomón, Horacio
Sued, Omar
Turk, Gabriela
Magdalena Gherardi, María
author_sort Falivene, Juliana
title Th17 and Th17/Treg ratio at early HIV infection associate with protective HIV-specific CD8+ T-cell responses and disease progression
title_short Th17 and Th17/Treg ratio at early HIV infection associate with protective HIV-specific CD8+ T-cell responses and disease progression
title_full Th17 and Th17/Treg ratio at early HIV infection associate with protective HIV-specific CD8+ T-cell responses and disease progression
title_fullStr Th17 and Th17/Treg ratio at early HIV infection associate with protective HIV-specific CD8+ T-cell responses and disease progression
title_full_unstemmed Th17 and Th17/Treg ratio at early HIV infection associate with protective HIV-specific CD8+ T-cell responses and disease progression
title_sort th17 and th17/treg ratio at early hiv infection associate with protective hiv-specific cd8+ t-cell responses and disease progression
description The aim of this study was to analyze Th17 and Treg subsets and their correlation with anti-HIV T-cell responses and clinical parameters during (acute/early) primary HIV infection (PHI) and up to one year post-infection (p.i). Samples from 14 healthy donors (HDs), 40 PHI patients, 17 Chronics, and 13 Elite controllers (ECs) were studied. The percentages of Th17 and Treg subsets were severely altered in Chronics, whereas all HIV-infected individuals (including ECs) showed Th17/Treg imbalance compared to HDs, in concordance with higher frequencies of activated CD8+ T-cells (HLA-DR+/CD38+). Better clinical status (higher CD4 counts, lower viral loads and activation) was associated with higher Th17 and lower Treg levels. We found positive correlations between Th17 at baseline and anti-HIV CD8+ T-cell functionality: viral inhibitory activity (VIA) and key polyfunctions (IFN-γ+/CD107A/B+) at both early and later times p.i, highlighting the prognostic value of Th17 cells to preserve an effective HIV T-cell immunity. Th17/Treg ratio and the IL-17 relative mean fluorescence intensity (rMFI of IL-17) were also positively correlated with VIA. Taken together, our results suggested a potential link between Th17 and Th17/Treg ratio with key HIV-specific CD8+ T-cell responses against the infection.
publisher Nature Publishing Group
publishDate 2015
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477236/
_version_ 1613239029560508416

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