Latent and Active Tuberculosis Infection Increase Immune Activation in Individuals Co-Infected with HIV☆☆☆★

•While HIV co-infection is known to exacerbate TB, little is known about the effect of latent TB infection on HIV disease.•In HIV-infected individuals, active and latent TB elevate immunological biomarkers of HIV morbidity and mortality.•In the context of HIV, latent TB infection may be associated w...

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Main Authors:	Sullivan, Zuri A., Wong, Emily B., Ndung'u, Thumbi, Kasprowicz, Victoria O., Bishai, William R.
Format:	Online
Language:	English
Published:	Elsevier 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476549/

id	pubmed-4476549
recordtype	oai_dc
spelling	pubmed-44765492015-07-01 Latent and Active Tuberculosis Infection Increase Immune Activation in Individuals Co-Infected with HIV☆☆☆★ Sullivan, Zuri A. Wong, Emily B. Ndung'u, Thumbi Kasprowicz, Victoria O. Bishai, William R. Original Article •While HIV co-infection is known to exacerbate TB, little is known about the effect of latent TB infection on HIV disease.•In HIV-infected individuals, active and latent TB elevate immunological biomarkers of HIV morbidity and mortality.•In the context of HIV, latent TB infection may be associated with increased risk of progression to AIDS and mortality.•In addition to reducing TB transmission, aggressive treatment of latent TB infection may also reduce the progression of HIV. Elsevier 2015-03-10 /pmc/articles/PMC4476549/ /pubmed/26114158 http://dx.doi.org/10.1016/j.ebiom.2015.03.005 Text en © 2015 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Sullivan, Zuri A. Wong, Emily B. Ndung'u, Thumbi Kasprowicz, Victoria O. Bishai, William R.
spellingShingle	Sullivan, Zuri A. Wong, Emily B. Ndung'u, Thumbi Kasprowicz, Victoria O. Bishai, William R. Latent and Active Tuberculosis Infection Increase Immune Activation in Individuals Co-Infected with HIV☆☆☆★
author_facet	Sullivan, Zuri A. Wong, Emily B. Ndung'u, Thumbi Kasprowicz, Victoria O. Bishai, William R.
author_sort	Sullivan, Zuri A.
title	Latent and Active Tuberculosis Infection Increase Immune Activation in Individuals Co-Infected with HIV☆☆☆★
title_short	Latent and Active Tuberculosis Infection Increase Immune Activation in Individuals Co-Infected with HIV☆☆☆★
title_full	Latent and Active Tuberculosis Infection Increase Immune Activation in Individuals Co-Infected with HIV☆☆☆★
title_fullStr	Latent and Active Tuberculosis Infection Increase Immune Activation in Individuals Co-Infected with HIV☆☆☆★
title_full_unstemmed	Latent and Active Tuberculosis Infection Increase Immune Activation in Individuals Co-Infected with HIV☆☆☆★
title_sort	latent and active tuberculosis infection increase immune activation in individuals co-infected with hiv☆☆☆★
description	•While HIV co-infection is known to exacerbate TB, little is known about the effect of latent TB infection on HIV disease.•In HIV-infected individuals, active and latent TB elevate immunological biomarkers of HIV morbidity and mortality.•In the context of HIV, latent TB infection may be associated with increased risk of progression to AIDS and mortality.•In addition to reducing TB transmission, aggressive treatment of latent TB infection may also reduce the progression of HIV.
publisher	Elsevier
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476549/
_version_	1613238753669677056

Latent and Active Tuberculosis Infection Increase Immune Activation in Individuals Co-Infected with HIV☆☆☆★

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