The effects of white matter hyperintensities and amyloid deposition on Alzheimer dementia

•White matter damage was quantified using the Fazekas rating scale.•Measures of amyloid were measured using positron emission tomography.•There was a greater severity of damage in demented individuals.•White matter damage significantly predicted dementia after controlling for amyloid.•There is a cli...

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Bibliographic Details
Main Authors: Gordon, Brian A., Najmi, Safa, Hsu, Phillip, Roe, Catherine M., Morris, John C., Benzinger, Tammie L.S.
Format: Online
Language:English
Published: Elsevier 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4474174/