Novel small-molecule SIRT1 inhibitors induce cell death in adult T-cell leukaemia cells

Novel small-molecule SIRT1 inhibitors induce cell death in adult T-cell leukaemia cells

Adult T-cell leukaemia/lymphoma (ATL) is an aggressive T-cell malignancy that develops after long-term infection with human T-cell leukaemia virus (HTLV)-1. The identification of new molecular targets for ATL prevention and treatment is desired. SIRT1, a nicotinamide adenine dinucleotide+ -dependent...

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Bibliographic Details
Main Authors: Kozako, Tomohiro, Suzuki, Takayoshi, Yoshimitsu, Makoto, Uchida, Yuichiro, Kuroki, Ayako, Aikawa, Akiyoshi, Honda, Shin-ichiro, Arima, Naomichi, Soeda, Shinji
Format: Online
Language:English
Published: Nature Publishing Group 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4473680/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4473680/

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