The gut microbiota of nonalcoholic fatty liver disease: current methods and their interpretation

The gut microbiota of nonalcoholic fatty liver disease: current methods and their interpretation

The role of intestinal bacteria in the pathogenesis of nonalcoholic fatty liver disease is increasingly acknowledged. Recently developed microbial profiling techniques are beginning to shed light on the nature of gut microbiota alterations in nonalcoholic fatty liver disease. In this review, we summ...

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Main Authors: van Best, Niels, Jansen, Peter L., Rensen, Sander S.
Format: Online
Language:English
Published: Springer India 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4473019/
id pubmed-4473019
recordtype oai_dc
spelling pubmed-44730192015-06-22 The gut microbiota of nonalcoholic fatty liver disease: current methods and their interpretation van Best, Niels Jansen, Peter L. Rensen, Sander S. Review Article The role of intestinal bacteria in the pathogenesis of nonalcoholic fatty liver disease is increasingly acknowledged. Recently developed microbial profiling techniques are beginning to shed light on the nature of gut microbiota alterations in nonalcoholic fatty liver disease. In this review, we summarize the gut microbiota composition changes that have been reported during different stages of human nonalcoholic fatty liver disease, and highlight the relation between bile acids and gut bacteria in this context. In addition, we discuss the different methodologies used in microbiota analyses as well as the interpretation of microbiota data. Whereas the currently available studies have provided useful information, future large-scale prospective studies with carefully phenotyped subjects and sequential sampling will be required to demonstrate a causal role of gut microbiota changes in the etiology of nonalcoholic fatty liver disease. Springer India 2015-06-12 /pmc/articles/PMC4473019/ /pubmed/26067771 http://dx.doi.org/10.1007/s12072-015-9640-2 Text en © The Author(s) 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author van Best, Niels
Jansen, Peter L.
Rensen, Sander S.
spellingShingle van Best, Niels
Jansen, Peter L.
Rensen, Sander S.
The gut microbiota of nonalcoholic fatty liver disease: current methods and their interpretation
author_facet van Best, Niels
Jansen, Peter L.
Rensen, Sander S.
author_sort van Best, Niels
title The gut microbiota of nonalcoholic fatty liver disease: current methods and their interpretation
title_short The gut microbiota of nonalcoholic fatty liver disease: current methods and their interpretation
title_full The gut microbiota of nonalcoholic fatty liver disease: current methods and their interpretation
title_fullStr The gut microbiota of nonalcoholic fatty liver disease: current methods and their interpretation
title_full_unstemmed The gut microbiota of nonalcoholic fatty liver disease: current methods and their interpretation
title_sort gut microbiota of nonalcoholic fatty liver disease: current methods and their interpretation
description The role of intestinal bacteria in the pathogenesis of nonalcoholic fatty liver disease is increasingly acknowledged. Recently developed microbial profiling techniques are beginning to shed light on the nature of gut microbiota alterations in nonalcoholic fatty liver disease. In this review, we summarize the gut microbiota composition changes that have been reported during different stages of human nonalcoholic fatty liver disease, and highlight the relation between bile acids and gut bacteria in this context. In addition, we discuss the different methodologies used in microbiota analyses as well as the interpretation of microbiota data. Whereas the currently available studies have provided useful information, future large-scale prospective studies with carefully phenotyped subjects and sequential sampling will be required to demonstrate a causal role of gut microbiota changes in the etiology of nonalcoholic fatty liver disease.
publisher Springer India
publishDate 2015
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4473019/
_version_ 1613237677453213696

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