Glycogen synthase kinase-3 (Gsk-3) plays a fundamental role in maintaining DNA methylation at imprinted loci in mouse embryonic stem cells

Glycogen synthase kinase-3 (Gsk-3) plays a fundamental role in maintaining DNA methylation at imprinted loci in mouse embryonic stem cells

A genome-wide analysis is given of DNA methylation in mouse embryonic stem cells in which both Gsk-3α and Gsk-3β have been genetically deleted. DNA methylation patterns are compared to those of wild-type cells. More than 75% of known imprinted loci have reduced DNA methylation in the Gsk-3–knockout...

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Bibliographic Details
Main Authors: Meredith, Gavin D., D'Ippolito, Anthony, Dudas, Miroslav, Zeidner, Leigh C., Hostetter, Logan, Faulds, Kelsie, Arnold, Thomas H., Popkie, Anthony P., Doble, Bradley W., Marnellos, George, Adams, Christopher, Wang, Yulei, Phiel, Christopher J.
Format: Online
Language:English
Published: The American Society for Cell Biology 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4472022/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4472022/

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