Cyclin-dependent kinase 5 acts as a critical determinant of AKT-dependent proliferation and regulates differential gene expression by the androgen receptor in prostate cancer cells

Cyclin-dependent kinase 5 acts as a critical determinant of AKT-dependent proliferation and regulates differential gene expression by the androgen receptor in prostate cancer cells

CDK5 acts as a signaling hub in prostate cancer cells by controlling androgen responses through AR stabilization and specific gene targeting, maintaining and accelerating cell proliferation through activation of the oncogenic AKT kinase, and releasing cell cycle breaks in a variety of prostate cance...

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Bibliographic Details
Main Authors: Lindqvist, Julia, Imanishi, Susumu Y., Torvaldson, Elin, Malinen, Marjo, Remes, Mika, Örn, Fanny, Palvimo, Jorma J., Eriksson, John E.
Format: Online
Language:English
Published: The American Society for Cell Biology 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4472009/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4472009/

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