How a homolog of high-fidelity replicases conducts mutagenic DNA synthesis
All DNA replicases achieve high fidelity by a conserved mechanism, but each translesion polymerase carries out mutagenic DNA synthesis in its own way. Here we report crystal structures of human DNA polymerase ν (Pol ν), which is homologous to high-fidelity replicases and yet error-prone. Instead of...
| Main Authors: | , , |
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| Format: | Online |
| Language: | English |
| Published: |
2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4469489/ |