The proportion of postmenopausal breast cancer cases in the Netherlands attributable to lifestyle-related risk factors

We aimed to estimate the proportion of Dutch postmenopausal breast cancer cases in 2010 that is attributable to lifestyle-related risk factors. We calculated population attributable fractions (PAFs) of potentially modifiable risk factors for postmenopausal breast cancer in Dutch women aged >50 in...

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Main Authors:	van Gemert, W. A., Lanting, C. I., Goldbohm, R. A., van den Brandt, P. A., Grooters, H. G., Kampman, E., Kiemeney, L. A. L. M., van Leeuwen, F. E., Monninkhof, E. M., de Vries, E., Peeters, P. H., Elias, S. G.
Format:	Online
Language:	English
Published:	Springer US 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4469298/

id	pubmed-4469298
recordtype	oai_dc
spelling	pubmed-44692982015-06-17 The proportion of postmenopausal breast cancer cases in the Netherlands attributable to lifestyle-related risk factors van Gemert, W. A. Lanting, C. I. Goldbohm, R. A. van den Brandt, P. A. Grooters, H. G. Kampman, E. Kiemeney, L. A. L. M. van Leeuwen, F. E. Monninkhof, E. M. de Vries, E. Peeters, P. H. Elias, S. G. Epidemiology We aimed to estimate the proportion of Dutch postmenopausal breast cancer cases in 2010 that is attributable to lifestyle-related risk factors. We calculated population attributable fractions (PAFs) of potentially modifiable risk factors for postmenopausal breast cancer in Dutch women aged >50 in 2010. First, age-specific PAFs were calculated for each risk factor, based on their relative risks for postmenopausal breast cancer (from meta-analyses) and age-specific prevalence in the population (from national surveys) around the year 2000, assuming a latency period of 10 years. To obtain the overall PAF, age-specific PAFs were summed in a weighted manner, using the age-specific breast cancer incidence rates (2010) as weights. 95 % confidence intervals for PAF estimates were derived by Monte Carlo simulations. Of Dutch women >40 years, in 2000, 51 % were overweight/obese, 55 % physically inactive (<5 days/week 30 min activity), 75 % regularly consumed alcohol, 42 % ever smoked cigarettes and 79 % had a low-fibre intake (<3.4 g/1000 kJ/day). These factors combined had a PAF of 25.7 % (95 % CI 24.2–27.2), corresponding to 2,665 Dutch postmenopausal breast cancer cases in 2010. PAFs were 8.8 % (95 % CI 6.3–11.3) for overweight/obesity, 6.6 % (95 % CI 5.2–8.0) for alcohol consumption, 5.5 % (95 % CI 4.0–7.0) for physical inactivity, 4.6 % (95 % CI 3.3–6.0) for smoking and 3.2 % (95 % CI 1.6–4.8) for low-fibre intake. Our findings imply that modifiable risk factors are jointly responsible for approximately one out of four Dutch postmenopausal breast cancer cases. This suggests that incidence rates can be lowered substantially by living a more healthy lifestyle. Springer US 2015-06-05 2015 /pmc/articles/PMC4469298/ /pubmed/26044369 http://dx.doi.org/10.1007/s10549-015-3447-7 Text en © The Author(s) 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	van Gemert, W. A. Lanting, C. I. Goldbohm, R. A. van den Brandt, P. A. Grooters, H. G. Kampman, E. Kiemeney, L. A. L. M. van Leeuwen, F. E. Monninkhof, E. M. de Vries, E. Peeters, P. H. Elias, S. G.
spellingShingle	van Gemert, W. A. Lanting, C. I. Goldbohm, R. A. van den Brandt, P. A. Grooters, H. G. Kampman, E. Kiemeney, L. A. L. M. van Leeuwen, F. E. Monninkhof, E. M. de Vries, E. Peeters, P. H. Elias, S. G. The proportion of postmenopausal breast cancer cases in the Netherlands attributable to lifestyle-related risk factors
author_facet	van Gemert, W. A. Lanting, C. I. Goldbohm, R. A. van den Brandt, P. A. Grooters, H. G. Kampman, E. Kiemeney, L. A. L. M. van Leeuwen, F. E. Monninkhof, E. M. de Vries, E. Peeters, P. H. Elias, S. G.
author_sort	van Gemert, W. A.
title	The proportion of postmenopausal breast cancer cases in the Netherlands attributable to lifestyle-related risk factors
title_short	The proportion of postmenopausal breast cancer cases in the Netherlands attributable to lifestyle-related risk factors
title_full	The proportion of postmenopausal breast cancer cases in the Netherlands attributable to lifestyle-related risk factors
title_fullStr	The proportion of postmenopausal breast cancer cases in the Netherlands attributable to lifestyle-related risk factors
title_full_unstemmed	The proportion of postmenopausal breast cancer cases in the Netherlands attributable to lifestyle-related risk factors
title_sort	proportion of postmenopausal breast cancer cases in the netherlands attributable to lifestyle-related risk factors
description	We aimed to estimate the proportion of Dutch postmenopausal breast cancer cases in 2010 that is attributable to lifestyle-related risk factors. We calculated population attributable fractions (PAFs) of potentially modifiable risk factors for postmenopausal breast cancer in Dutch women aged >50 in 2010. First, age-specific PAFs were calculated for each risk factor, based on their relative risks for postmenopausal breast cancer (from meta-analyses) and age-specific prevalence in the population (from national surveys) around the year 2000, assuming a latency period of 10 years. To obtain the overall PAF, age-specific PAFs were summed in a weighted manner, using the age-specific breast cancer incidence rates (2010) as weights. 95 % confidence intervals for PAF estimates were derived by Monte Carlo simulations. Of Dutch women >40 years, in 2000, 51 % were overweight/obese, 55 % physically inactive (<5 days/week 30 min activity), 75 % regularly consumed alcohol, 42 % ever smoked cigarettes and 79 % had a low-fibre intake (<3.4 g/1000 kJ/day). These factors combined had a PAF of 25.7 % (95 % CI 24.2–27.2), corresponding to 2,665 Dutch postmenopausal breast cancer cases in 2010. PAFs were 8.8 % (95 % CI 6.3–11.3) for overweight/obesity, 6.6 % (95 % CI 5.2–8.0) for alcohol consumption, 5.5 % (95 % CI 4.0–7.0) for physical inactivity, 4.6 % (95 % CI 3.3–6.0) for smoking and 3.2 % (95 % CI 1.6–4.8) for low-fibre intake. Our findings imply that modifiable risk factors are jointly responsible for approximately one out of four Dutch postmenopausal breast cancer cases. This suggests that incidence rates can be lowered substantially by living a more healthy lifestyle.
publisher	Springer US
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4469298/
_version_	1613236305246814208

The proportion of postmenopausal breast cancer cases in the Netherlands attributable to lifestyle-related risk factors

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