Inhibitors of pan-PI3K Signaling Synergize with BRAF or MEK Inhibitors to Prevent BRAF-Mutant Melanoma Cell Growth

Inhibitors of pan-PI3K Signaling Synergize with BRAF or MEK Inhibitors to Prevent BRAF-Mutant Melanoma Cell Growth

BRAF and MEK inhibitors have improved outcomes for patients with BRAF-mutant melanoma, but their efficacy is limited by both intrinsic and acquired resistances. Activation of the PI3K pathway can mediate resistance to these agents, providing a strong rationale for combination therapy in melanoma. He...

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Bibliographic Details
Main Authors: Sweetlove, Melanie, Wrightson, Emma, Kolekar, Sharada, Rewcastle, Gordon W., Baguley, Bruce C., Shepherd, Peter R., Jamieson, Stephen M. F.
Format: Online
Language:English
Published: Frontiers Media S.A. 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468830/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468830/

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