Discordant Impact of HLA on Viral Replicative Capacity and Disease Progression in Pediatric and Adult HIV Infection

Discordant Impact of HLA on Viral Replicative Capacity and Disease Progression in Pediatric and Adult HIV Infection

HLA class I polymorphism has a major influence on adult HIV disease progression. An important mechanism mediating this effect is the impact on viral replicative capacity (VRC) of the escape mutations selected in response to HLA-restricted CD8+ T-cell responses. Factors that contribute to slow progre...

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Bibliographic Details
Main Authors: Adland, Emily, Paioni, Paolo, Thobakgale, Christina, Laker, Leana, Mori, Luisa, Muenchhoff, Maximilian, Csala, Anna, Clapson, Margaret, Flynn, Jacquie, Novelli, Vas, Hurst, Jacob, Naidoo, Vanessa, Shapiro, Roger, Huang, Kuan-Hsiang Gary, Frater, John, Prendergast, Andrew, Prado, Julia G., Ndung’u, Thumbi, Walker, Bruce D., Carrington, Mary, Jooste, Pieter, Goulder, Philip J. R.
Format: Online
Language:English
Published: Public Library of Science 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468173/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468173/

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