Palmitate Inhibits SIRT1-Dependent BMAL1/CLOCK Interaction and Disrupts Circadian Gene Oscillations in Hepatocytes

Palmitate Inhibits SIRT1-Dependent BMAL1/CLOCK Interaction and Disrupts Circadian Gene Oscillations in Hepatocytes

Elevated levels of serum saturated fatty acid palmitate have been shown to promote insulin resistance, increase cellular ROS production, and trigger cell apoptosis in hepatocytes during the development of obesity. However, it remains unclear whether palmitate directly impacts the circadian clock in...

Full description

Bibliographic Details
Main Authors: Tong, Xin, Zhang, Deqiang, Arthurs, Blake, Li, Pei, Durudogan, Leigh, Gupta, Neil, Yin, Lei
Format: Online
Language:English
Published: Public Library of Science 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468094/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468094/

Similar Items