Inhibition of non-small cell lung cancer (NSCLC) growth by a novel small molecular inhibitor of EGFR

Inhibition of non-small cell lung cancer (NSCLC) growth by a novel small molecular inhibitor of EGFR

The epidermal growth factor receptor (EGFR) is a therapeutic target (oncotarget) in NSCLC. Using in vitro EGFR kinase activity system, we identified a novel small molecule, WB-308, as an inhibitor of EGFR. WB-308 decreased NSCLC cell proliferation and colony formation, by causing G2/M arrest and apo...

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Bibliographic Details
Main Authors: Li, Jinsong, Deng, Huayun, Hu, Meichun, Fang, Yuanzhang, Vaughn, Amanda, Cai, Xiaopan, Xu, Leqin, Wan, Wei, Li, Zhenxi, Chen, Shijie, Yang, Xinghai, Wu, Song, Xiao, Jianru
Format: Online
Language:English
Published: Impact Journals LLC 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466647/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466647/

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