Constitutive activation of the DNA damage response pathway as a novel therapeutic target in diffuse large B-cell lymphoma

Constitutive activation of the DNA damage response pathway as a novel therapeutic target in diffuse large B-cell lymphoma

The recent finding that MYC-driven cancers are sensitive to inhibition of the DNA damage response (DDR) pathway, prompted us to investigate the role of DDR pathway as therapeutic target in diffuse large B-cell lymphoma (DLBCL), which frequently overexpresses the MYC oncogene. In a preliminary immuno...

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Bibliographic Details
Main Authors: Derenzini, Enrico, Agostinelli, Claudio, Imbrogno, Enrica, Iacobucci, Ilaria, Casadei, Beatrice, Brighenti, Elisa, Righi, Simona, Fuligni, Fabio, Di Rorà, Andrea Ghelli Luserna, Ferrari, Anna, Martinelli, Giovanni, Pileri, Stefano, Zinzani, Pier Luigi
Format: Online
Language:English
Published: Impact Journals LLC 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466634/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466634/

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