Characterization of Imidazopyridine Compounds as Negative Allosteric Modulators of Proton-Sensing GPR4 in Extracellular Acidification-Induced Responses

Characterization of Imidazopyridine Compounds as Negative Allosteric Modulators of Proton-Sensing GPR4 in Extracellular Acidification-Induced Responses

G protein-coupled receptor 4 (GPR4), previously proposed as the receptor for sphingosylphosphorylcholine, has recently been identified as the proton-sensing G protein-coupled receptor (GPCR) coupling to multiple intracellular signaling pathways, including the Gs protein/cAMP and G13 protein/Rho. In...

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Bibliographic Details
Main Authors: Tobo, Ayaka, Tobo, Masayuki, Nakakura, Takashi, Ebara, Masashi, Tomura, Hideaki, Mogi, Chihiro, Im, Dong-Soon, Murata, Naoya, Kuwabara, Atsushi, Ito, Saki, Fukuda, Hayato, Arisawa, Mitsuhiro, Shuto, Satoshi, Nakaya, Michio, Kurose, Hitoshi, Sato, Koichi, Okajima, Fumikazu
Format: Online
Language:English
Published: Public Library of Science 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466532/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466532/

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