The impact of stress and glucocorticoids on memory

The impact of stress and glucocorticoids on memory

Responses to stress are mediated by a complex network of the nervous and endocrine systems. Glucocorticoids, which are among the most important “players” in stress resilience, may have important implications in the cognitive functions, particularly in the modulation of memory. Declarative memory, th...

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Main Authors: TATOMIR, ALEXANDRU, MICU, CARMEN, CRIVII, CARMEN
Format: Online
Language:English
Published: Iuliu Hatieganu University of Medicine and Pharmacy 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4462413/
id pubmed-4462413
recordtype oai_dc
spelling pubmed-44624132015-11-02 The impact of stress and glucocorticoids on memory TATOMIR, ALEXANDRU MICU, CARMEN CRIVII, CARMEN Reviews Responses to stress are mediated by a complex network of the nervous and endocrine systems. Glucocorticoids, which are among the most important “players” in stress resilience, may have important implications in the cognitive functions, particularly in the modulation of memory. Declarative memory, the memory for facts, events and word meaning is the most studied type of memory on which glucocorticoids exert an influence, both positively through consolidation and negatively through impairment. These effects depend on the receptor type, dose, time of exposure, memory component and the salience of stimuli, retrieval being generally affected and storage being facilitated, especially for emotionally relevant events. Glucocorticoids also induce hippocampal atrophy, which is a hallmark seen in various diseases accompanied by a chronic high level of cortisol, such as the Cushing syndrome, major depression, post-traumatic stress disorder. Also, chronic stress might be a risk factor for the development of Alzheimer’s disease, especially when a genetic background and other environmental influences are present. Iuliu Hatieganu University of Medicine and Pharmacy 2014 2014-01-30 /pmc/articles/PMC4462413/ /pubmed/26527987 http://dx.doi.org/10.15386/cjm.2014.8872.871.at1cm2 Text en http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author TATOMIR, ALEXANDRU
MICU, CARMEN
CRIVII, CARMEN
spellingShingle TATOMIR, ALEXANDRU
MICU, CARMEN
CRIVII, CARMEN
The impact of stress and glucocorticoids on memory
author_facet TATOMIR, ALEXANDRU
MICU, CARMEN
CRIVII, CARMEN
author_sort TATOMIR, ALEXANDRU
title The impact of stress and glucocorticoids on memory
title_short The impact of stress and glucocorticoids on memory
title_full The impact of stress and glucocorticoids on memory
title_fullStr The impact of stress and glucocorticoids on memory
title_full_unstemmed The impact of stress and glucocorticoids on memory
title_sort impact of stress and glucocorticoids on memory
description Responses to stress are mediated by a complex network of the nervous and endocrine systems. Glucocorticoids, which are among the most important “players” in stress resilience, may have important implications in the cognitive functions, particularly in the modulation of memory. Declarative memory, the memory for facts, events and word meaning is the most studied type of memory on which glucocorticoids exert an influence, both positively through consolidation and negatively through impairment. These effects depend on the receptor type, dose, time of exposure, memory component and the salience of stimuli, retrieval being generally affected and storage being facilitated, especially for emotionally relevant events. Glucocorticoids also induce hippocampal atrophy, which is a hallmark seen in various diseases accompanied by a chronic high level of cortisol, such as the Cushing syndrome, major depression, post-traumatic stress disorder. Also, chronic stress might be a risk factor for the development of Alzheimer’s disease, especially when a genetic background and other environmental influences are present.
publisher Iuliu Hatieganu University of Medicine and Pharmacy
publishDate 2014
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4462413/
_version_ 1613233987042410496

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